RIZ1、CD133在浆液性卵巢癌组织中的表达及其临床意义

Relationship of RIZ1 and CD133 Expression Levels with Development of Serous Ovarian Cancer

【目的】探讨视网膜母细胞瘤蛋白结合辞指结构基因(RIZ1)、5次跨膜蛋白(CD133)在浆液性卵巢癌组织中的表达及其临床意义。【方法】选取2018年1月至2019年6月在本院确诊的卵巢癌组织标本70例(卵巢癌组)、因子宫肌瘤手术获取的正常卵巢组织标本70例(对照组),采用免疫组化染色检测两组标本中的RIZ1蛋白、CD133蛋白表达水平,比较卵巢癌组中不同组织学分级、不同FIGO分期、有无淋巴结转移的RIZ1蛋白、CD133蛋白表达水平。【结果】卵巢癌组织中的RIZ1蛋白阳性表达率为32.86%(23/70),显著低于对照组的85.71%(60/70);CD133蛋白阳性表达率为51.43%(36/70),显著高于对照组的11.43%(8/70),其差异均具有统计学意义(P<0.05)。不同组织学分化程度的卵巢癌组织中的RIZ1蛋白阳性表达率比较差异有统计学意义(P<0.05),但在不同FIGO分期、是否发生淋巴结转移的卵巢癌组织中比较差异无统计学意义(P>0.05);不同组织学分化程度、不同FIGO分期、是否发生淋巴结转移的卵巢癌组织中的CD133的阳性表达率比较差异均具有统计学意义(P<0.05)。【结论】浆液性卵巢癌组织中RIZ1蛋白表达下调、CD133蛋白表达上调,且其均与肿瘤的发生、发展密切相关。

【Objective】To investigate the expression and clinical significance of retinoblastoma protein-binding zinc finger structure gene(RIZ1)and 5-time transmembrane protein(CD133)in serous ovarian cancer tissues.iMethodsjWe selected 70 cases of ovarian cancer patients(ovarian cancer group)and 70 cases of normal ovarian tissue obtained from surgery of uterine fibroids in our hospital from January 2017 to June 2018(the control group).Expression levels of RIZ1 protein and CD133 protein in the two groups were detected by immunohistochemical staining and analyzed hierarchically according to histological grade,FIGO stage and lymph node metastasis.【Results】The positive expression rates of RIZ1 protein and CD133 protein in ovarian cancer tissues were 32.86%(23/70)and 51.43%(36/70),respectively.The positive expression rates of RIZ1 protein and CD133 protein in the control group were 85.71%(60/70)and 11.43%(8/70),respectively.The difference between the two groups was statistically significant(P<0.05).The difference in positive expression rate of RIZ1 protein in ovarian cancer tissues of patients with different histological differentiation was statistically significant(P<0.05).However,the difference in positive expression rate of RIZ1 protein in ovarian cancer patients with different FIGO stages and lymph node metastasis was not statistically significant(P>0.05).The differences in positive expression rate of CD133 in ovarian cancer tissues of patients with different histological differentiation,different FIGO stages,and whether lymph node metastasis occurred were statisti-cally significant(P<0.05).【Conclusion】The expression of RIZ1 protein is down-regulated and the expression of GDI33 protein is up-regulated in serous ovarian cancer tissues.These are closely related to the occurrence and development of tumors.