血清hs-CRP和sST2与急性冠脉综合征患者病情及预后的相关性

Correlation of Serum hs CRP and sST2 with the Condition and Prognosis of Patients with Acute Coronary Syndrome

【目的】探讨血清超敏C反应蛋白(hs-CRP),可溶性生长刺激表达基因2蛋白(sST2)与急性冠脉综合征(ACS)患者病情及预后的相关性。【方法】60例ACS患者作为ACS组,选取同期健康体检者60例作为对照组。检测两组受试者血清hs-CRP、sST2水平,绘制受试者工作特征曲线(ROC)分析二者对ACS的预测价值。经Pearson线性相关分析血清hs-CRP、sST2水平与全球急性冠状动脉事件注册评分(GRACE)的相关性。根据ACS患者的预后情况,分成预后良好组、预后不良组,比较两组血清hs-CRP、sST2水平,分析二者对患者预后的预测价值。【结果】ACS组的血清hs-CRP、sST2均高于对照组(P<0.05)。血清hs-CRP、sST2预测ACS的曲线下面积分别为0.648、0.746,当hs-CRP>14.650 mg/L、sST2>15.275 ng/mL时,ACS发生风险更高。ACS患者的GRACE评分为(125.32±34.76)分,Pearson线性相关分析提示血清hs-CRP、sST2与GRACE评分呈正相关(均PC0.05)。60例ACS患者中,预后不良15例,预后良好45例。预后不良组血清hs-CRP、sST2显著高于预后良好组(P<0.05)。血清hs-CRP、sST2预测ACS预后不良的曲线下面积分别为0.676、0.694,当hs-CRP>15.420 mg/L、sST2>23.500 ng/mL时,ACS预后不良风险更高.【结论】血清hs-CRP、sST2对ACS具有一定预测价值,二者与ACS患者的GRACE评分呈正相关,且能作为预测ACS患者预后的重要指标。

[Objective]Objective to investigate the correlation between serum high sensitivity C-reactive protein(hs CRP),soluble growth stimulating gene 2 protein(sST2)and the condition and prognosis of patients with acute coronary syndrome(ACS).【Methods】Sixty patients with ACS were selected as ACS group,and 60 healthy people were selected as control group.The serum hs CRP and sST2 levels of the two groups were detected t and the receiver operating characteristic curve(ROC)was drawn to analyze their predictive value for ACS.Pearson linear correlation was used to analyze the correlation between serum hs CRP,sST2 levels and grace.According to the prognosis of ACS patients,they were divided into good prognosis group and poor prognosis group.The serum hs CRP and sST2 levels of the two groups were compared,and the predictive value of the two groups for the prognosis of patients was ana-lyzed.【Results】The serum hs CRP and sST2 in ACS group were higher than those in control group(P<0.05).The area under the curve of serum hs CRP and sST2 in predicting ACS was 0.648 and 0.746 respectively.When hs CRP〉14.650 mg/L and sST2〉15.275 ng/ml,the risk of ACS was higher.The grace score of ACS patients was(125.32±34.76).Pearson linear correlation analysis showed that serum hs CRP and sST2 were positively correlated with grace score(all P<0.05).of the 60 patients with ACS,15 had poor prognosis and 45 had good prognosis.The serum hs CRP and sST2 in poor prognosis group were significantly higher than those in good prognosis group(P<0.05).The area under the curve of serum hs CRP and sST2 in predicting poor prognosis of ACS was 0.676 and 0.694 respectively.When hs CRP>15.420 mg/L and sST2>23.500 ng/mL,the risk of poor prognosis of ACS was higher.【Conclusion】Serum hs CRP and sST2 have a certain predictive value for ACS.They are positively correlated with grace score of ACS patients,and can be used as important indicators to predict the prognosis of ACS patients.