FGF-21、Apelin在妊娠合并甲减患者血清中的水平表达及其与血脂水平、低体重新生儿发生率的相关性分析

Expression of Serum FGF-21 and Apelin in Pregnant Women with Hypothyroidism and Correlation with Blood Lipids and Low Birth Weight Neonates

【目的】探讨成纤维细胞生长因子21(FGF-21)、爱帕琳肽(Apelin)在妊娠合并甲状腺功能减退症(简称甲减)患者血清中的水平表达及其与血脂水平、低体重新生儿发生率相关性。【方法】选择2018年1月至2019年6月在宝鸡市第三医院妇产科诊治的85例妊娠期甲减患者为观察组,另选取同期在同院正常体检孕妇90例为对照组。对比两组患者甲状腺激素水平、血脂水平、血清FGF-21、Apelin表达水平,并分析血清FGF-21、Apelin表达与血脂水平及低体重新生儿发生率的相关性。【结果】观察组促甲状腺激素(TSH)水平明显高于对照组(P<0.05);游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)水平明显低于对照组(P<0.05);观察组FGF-21、Apelin、三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)水平明显高于对照组,低密度脂蛋白胆固醇(LDL-C)水平明显低于对照组,其差异均有统计学意义(均P<0.05);观察组低体重新生儿发生率为2.35%(2/85),显著低于对照组的10.00%(9/90),其差异有统计学意义(χ^(2)=4.340,P=0.037);相关性分析结果显示:妊娠合并甲减患者血清FGF-21、Apelin水平与TG、TC、低体重新生儿发生率呈正相关(P<0.05),与LDL呈负相关(P<0.05),与HDL无明显相关(P>0.05)。【结论】妊娠期甲减患者血清Apelin、FGF-21表达水平上升,且其表达与TG、TC等脂代谢指标呈正相关,分析其可能通过影响患者的代谢水平参与疾病的发生、发展,最终影响围产儿结局。

【Objective】To investigate the expression of serum fibroblast growth factor 21(FGF-21)and Apelin in pregnant patients with hypothyroidism and correlation with blood lipids and low-birthweight neonates.[Methods]From January 2018 to June 2019,85 patients with hypothyroidism during pregnancy were selected as the observation group,and 90 normal pregnant women were selected as the control group.Thyroid hormone levels,blood lipid levels,serum FGF-21,Apelin expression levels were compared between the two groups,and the correlation of serum FGF-21 and Apelin expression levels with blood lipid and low birth weight was analyzed.【Results】The TSH level of the observation group was significantly higher than that of the control group(P<0.05),while the levels of FT3(free triiodothyronine)and FT4(free thyroxine)were significantly lower than those in the control group(P<0.05).The levels of FGF-12,Apelin»TG,TC and HDL in the observation group were significantly higher than those in the control group(P<0.05),and the level of LDL in the observation group was significantly lower than that in the control group(P<0.05).The incidence of low birth weight newborns in the observation group was 2.35%(2/85),which was lower than 10.00%(9/90)in the control group.The difference was statistically significant between the two groups(χ^(2)=4.340,P=0.037).The results of correlation analysis showed that serum FGF-21 and Apelin levels in pregnant women with hypothyroidism were was positively correlated with TG,TC and the incidence of low neonatal weight(P<0.05),negatively correlated with LDL(P<0.05)and not significantly correlated with HDL(P〉0.05).【Conclusion】Serum Apelin and FGF-21 expression levels increased in patients with hypothyroidism during pregnancy,and the expression levels of Apelin and FGF-21 were posi tively correlated with lipid metabolism indicators such as TG and TC.It may participate in the occurrence and development of the disease by affecting the patients metabolic level,and ultimately affect the perinatal outcome.