祛痘中草药的筛选及其在治疗痤疮中的应用

Screening of anti-acne herbs and their application in the treatment of acne

利用抑菌和抑制5α-还原酶活性的效果为祛痘指标评价,从天然中草药中筛选出黄芩、丹参和连翘,并以这3种药材的醇提取物为功效成分制备成祛痘啫喱,检验临床应用效果。得出以此3种药材组成的复方对痤疮丙酸杆菌(P.acnes)和金黄色葡萄球菌(S.aureus)的最低抑制浓度(MIC)分别为3.13和3.13 mg/mL;在5 mg/mL下对5α-还原酶的抑制率为46.5%;并且祛痘啫喱能有效地减少痤疮的严重程度。结果表明,综合抑菌和抑制酶活性两方面作用,中草药黄芩、丹参和连翘显示出较好的效果,并具有良好的应用效果。

The anti-acne efficacy of herbs was evaluated according to their antibacterial effect and their inhibitory effect on 5α-reductase.Scutellaria Baicalensis,Salvia miltiorrhiza and Forsythia were thus screened from the Chinese herbs.An anti-acne gel was prepared in which the alcohol extracts of the three herbs were used as effective ingredients and its clinical effect was investigated.The minimum inhibitory concentrations(MIC)of the compound formula on P.acnes and S.aureus are 3.13 and 3.13 mg/mL,respectively.The inhibition rate against 5α-reductase at 5 mg/mL is 46.5%.This anti-acne gel can effectively reduce the severity of acne.The results indicate that the extracts of these three herbs show good antibacterial effect and enzyme inhibitory effect,and they have good application effect.