依克多因与羟基积雪草甙协同抗炎作用的研究

Studies on the synergistic anti-inflammatory effects of Ectoin and Madecassoside

采用LPS诱导RAW264.7细胞炎症模型证实了依克多因、羟基积雪草甙及依克多因与羟基积雪草甙组合配比在设定的质量浓度条件下,对LPS诱导的RAW264.7细胞产生NO均具有良好的抑制作用,即在细胞水平具有抗炎活性。同时依克多因与羟基积雪草甙组合在设定的不同质量浓度及配比下对NO的抑制率大多高于单一组分,并且依克多因与羟基积雪草甙组合在设定的不同质量浓度及配比下的SI值<1,以上说明依克多因与羟基积雪草甙组合在抗炎功效方面具有协同增效作用,关于其协同增效机理,需要进一步实验研究确定。

The inflammation model of RAW264.7 cells induced by LPS was used to detect that Ectoin,Madecassoside and their combination under different experimental set mass concentrations and ratios had good inhibitory effect on the production of NO in LPS-induced RAW264.7 cells,that is,it had anti-inflammatory activity at the cellular level.Meanwhile,under different experimental set mass concentrations and ratios,most of the combination of Ectoin and Madecassoside show higher inhibition rate of NO than that of a single component.In addition,the SI values under different experimental set mass concentrations and ratios are lower than 1.The above results demonstrate that the combination of Ectoin and Madecassoside has a synergistic interaction in anti-inflammatory,however,the mechanism needs further study.