正电子核素心肌代谢显像剂的研究进展

Research progress of positron radionuclide myocardial metabolism imaging agents

心肌细胞利用葡萄糖、脂肪酸、乳酸及酮体等多种底物产生能量,以维持自身的正常舒缩功能。心肌细胞能量代谢的异常改变与多种心脏疾病相关,如心肌缺血和心力衰竭等。放射性核素显像作为一种无创性功能检查方法,能够用于心肌细胞代谢状况的评价。放射性核素心肌代谢显像剂是由放射性核素标记的心肌代谢底物及其类似物,在临床上分为氧代谢显像剂、糖代谢显像剂和脂肪酸代谢显像剂。笔者就近年来有关正电子核素心肌代谢显像剂的研究进展进行综述。

Cardiomyocytes use various substrates such as glucose,fatty acids,lactic acid,and ketone bodies to produce energy to maintain their normal systolic and diastolic function.Abnormal changes in cardiomyocytes'energy metabolism are associated with various heart diseases,such as myocardial ischemia and heart failure.As a non-invasive functional examination method,radionuclide imaging can be used to evaluate the metabolism status of cardiomyocytes.Radionuclide myocardial metabolism imaging agents are myocardial metabolism substrates.Their analogues are labeled with radionuclides,divided into oxygen metabolism imaging agents,glucose metabolism imaging agents,and fatty acid metabolism imaging agents.This paper reviews the research progress of positron radionuclide myocardial metabolism imaging agents in recent years.