基于液芯MTC的低浓度血液葡萄糖光学传感器研究

Optical sensor for low concentration blood glucose detection based on liquid-core MTC

为了实现超低样本体积、高灵敏度的血液葡萄糖浓度检测,采用时域有限差分法分析了液芯微管腔(MTC)的壁厚和直径对回音壁模式(WGM)共振特性的影响。利用熔融拉锥法制备了MTC,通过高精度电控位移平台实现MTC和锥形光纤的高精度耦合以及WGM共振谱的激发,并对MTC进行表面功能化和过耦合方法以提高灵敏和稳定性,同时进行了理论分析和实验验证。结果表明,表面功能化的液芯MTC传感器取得的灵敏度约为0.911pm/(mmol·L^(-1)),线性度为0.988;该低浓度血液葡萄糖光学传感器的灵敏度和稳定性很高。这一结果对运动员训练中血糖的实时、快速监测,保障运动安全性和持久性等是有帮助的。

In order to achieve blood glucose concentration detection with ultra-low sample volume and high sensitivity,the influence of the wall thickness and diameter of liquid-core microtube cavity(MTC)on whispery gallery mode(WGM)resonance property was analyzed based on finite-difference time-domain(FDTD)method.The MTC was fabricated by melt-taping method.High-precision coupling of MTC and tapered fiber and the excitation of WGM resonance spectrum were realized by high-precision electronically controlled displacement platform.The surface functionalization and over-coupling methods of MTC were carried out to improve sensitivity and stability.Theoretical analysis and experimental verification have been carried out.The experimental results show that the linearity and sensitivity of the surface functionalized liquid-core MTC sensor are 0.988 and 0.911pm/(mmol·L^(-1)),respectively.The low-concentration blood glucose optical sensor has high sensitivity and stability.This result is helpful for real-time and rapid monitoring of blood sugar during training of athletes,and for ensuring the safety and durability of sports.