2009—2015年甘肃省肿瘤登记地区胰腺癌流行特征及变化趋势分析

Trends of incidence and mortality of pancreatic cancer in Gansu cancer registration areas,2009—2015

目的分析甘肃省肿瘤登记地区2009—2015年胰腺癌发病与死亡的流行特征及变化趋势,为制定胰腺癌的防治措施提供依据。方法按照全国肿瘤登记中心制订的审核方法和评价标准,评估甘肃省11个肿瘤登记地区上报的胰腺癌数据。分地区、性别、年龄别计算胰腺癌发病(死亡)率、中标发病(死亡)率、世标发病(死亡)率、0~74岁累积率及构成。运用年度变化百分比(Annual percentage change,APC)对胰腺癌中标发病(死亡)率进行时间趋势分析。结果2009—2015年甘肃省肿瘤登记地区胰腺癌新发病例1963例,发病率为5.18/10万(男性6.01/10万,女性4.31/10万),中标发病率为4.67/10万,世标发病率5.44/10万。同期胰腺癌死亡病例1708例,死亡率为4.51/10万(男性5.26/10万,女性3.72/10万),中标死亡率为3.78/10万,世标死亡率4.49/10万。农村地区中标发病率和中标死亡率(5.32/10万,4.63/10万)均高于城市地区(4.60/10万,3.54/10万)。胰腺癌发病率和死亡率均随年龄增长而上升,呈现男性高于女性的特点;2009—2015年甘肃省胰腺癌中标发病率和中标死亡率均呈现平稳趋势(APC=-4.2%,t=-1.6,P=0.2和APC=-3.6%,t=-1.1,P=0.1)。结论2009—2015年甘肃省胰腺癌的发病和死亡虽呈平稳趋势,但农村地区高于城市地区,其中中老年男性是胰腺癌的重点防控人群,应加强胰腺癌的病因学研究和早期诊断,有效控制胰腺癌的发生发展。

Objective The objective of this study was to analyze the epidemiological characteristics and changing trends of incidence and mortality of pancreatic cancer in cancer registration areas of Gansu province from 2009 to 2015,and provide the evidence for enacting prevention and treatment measures of pancreatic cancer.Methods According to the audit methods and standards established by the National Cancer Registration Center,the pancreatic cancer data reported by 11 cancer registration areas in Gansu province were evaluated.The incidence and mortality,age-standardized incidence/mortality rates by Chinese standard population(ASR China)and by World standard population(ASR World),the cumulative rate of 0~74 years old and composition were calculated by area,sex and age groups.The annual percentage change(APC)was used to analyze the time trend of the incidence and mortality by Chinese standard population of pancreatic cancer.Results From 2009 to 2015,there were 1963 new cases of pancreatic cancer in Gansu cancer registration areas.The incidence of pancreatic cancer in the cancer registration areas of Gansu province was 5.18/100000(6.01/100000 in male,4.31/100000 in female),the age-standardized incidence rates by Chinese standard population and by World standard population were 4.67/100000 and 5.44/100000.In the same period,there were 1708 deaths.The mortality was 4.51/100000(5.26/100000 in male,3.72/100000 in female),the age-standardized mortality rates by Chinese standard population and by World standard population were 3.78/100000 and 4.49/100000.The incidence and mortality by Chinese standard population in rural areas(5.32/100000,4.63/100000)were higher than those of in urban areas(4.60/100000,3.54/100000).The incidence and mortality of pancreatic cancer increased with age,which was higher in male than those in female.From 2009 to 2015,the incidence and mortality by Chinese standard population of pancreatic cancerin Gansu province showed a steady(APC=-4.2%,t=-1.6,P=0.2 and APC=-3.6%,t=-1.1,P=0.1).Conclusion From 2009 to 2015,the incidence and mortality of pancreatic cancer in Gansu province showed a stable trend,but they were higher in rural areas than those in urban areas.Among them,middle-aged and elderly men are the key population for the prevention and control of pancreatic cancer.The etiological research and early diagnosis of pancreatic cancer should be strengthened to effectively control the occurrence and development of pancreatic cancer.