2009—2015年甘肃省肿瘤登记地区宫颈癌流行特征及变化趋势分析

Epidemiological characteristics and trends of cervical cancer in cancer registries in Gansu province,2009—2015

目的分析2009—2015年甘肃省肿瘤登记地区宫颈癌发病与死亡现况及变化趋势,为制定宫颈癌防治策略提供依据。方法根据全国肿瘤登记中心制定的审核方法,收集甘肃省10个肿瘤登记点上报的2009—2015年宫颈癌数据,计算发病粗率、死亡粗率、中标率及世标率,中标率和世标率分别采用2000年中国标准人口年龄构成和Segi′s世界标准人口年龄构成计算,运用Joinpoint 4.7.0.0软件计算年度变化百分比(APC)。结果2009—2015年甘肃省肿瘤登记地区宫颈癌新发病例数3454例,发病粗率为18.75/10万,中标发病率为15.81/10万,世标发病率为15.95/10万,城市地区发病率(18.86/10万)高于农村地区(18.34/10万);死亡病例数2107例,死亡粗率为11.44/10万,中标死亡率为10.67/10万,世标死亡率为10.81/10万,城市地区死亡率(11.51/10万)高于农村地区(11.18/10万);2009—2015年宫颈癌年龄别发病率及年龄别死亡率随年龄增加而升高,发病率在50-岁年龄组达到高峰(52.64/10万),死亡率在80-岁年龄组达到高峰(47.29/10万);2009—2015年甘肃省宫颈癌发病粗率及死亡粗率呈下降趋势(APC=-0.9,P=0.9;APC=-4.3,P=0.5),趋势变化均无统计学意义。经年龄标化后,宫颈癌中标发病率及中标死亡率呈下降趋势(APC=-5.3,P=0.2;APC=-12.9,P=0.1),趋势变化均无统计学意义。结论甘肃省宫颈癌发病率及死亡率虽有下降趋势,但仍对中老年女性生命健康构成严重威胁,应积极开展宫颈癌防治知识的健康教育,提倡健康的生活方式,实现对宫颈癌的有效防控。

Objective The aim of this study was to analyze the incidence and mortality of cervical cancer in cancer registration areas of Gansu province from 2009 to 2015,and to provide the basis for the development of cervical cancer prevention and treatment strategies.Methods According to the audit methods of National Cancer Registry,data of cervical cancer reported by 10 cancer registration were collected from 2009 to 2015,calculate the crude incidence and crude mortality,ASR China and ASR World.ASR China and ASR World were calculated using the 2000 Chinese standard population age structure and Segi′s World standard population age structure,respectively.Annual percentage change(APC)was calculated using the JoinPoint Regression Program 4.7.0.0.Results From 2009 to 2015,there were 3454 new cases of cervical cancer in cancer registration areas of Gansu province.The crude incidence rate was 18.75/100000,the ASR China was 15.81/100000,and the ASR World was 15.95/100000.Incidence of the urban area(18.86/100000)were higher than the rural area(18.34/100000).There were 2107 death cases of cervical cancer in cancer registration areas of Gansu province,from 2009 to 2015.The mortality was 11.44/100000,the ASR China was 10.67/100000,and the ASR World was 10.81/100000.Mortality of the urban area(11.51/100000)was higher than the rural area(11.18/100000).From 2009 to 2015,the age-specific incidence and age-specific mortality of cervical cancer increased with the increase of age,and the incidence peaked in the 50-year-old group(52.64/100000),and the mortality peaked in the 80-year-old group(47.29/100000).The crude incidence and crude mortality rate of cervical cancer in Gansu province showed a decreasing trend from 2009 to 2015(APC=-0.9,P=0.9;APC=-4.3,P=0.5),there was no statistically significant change in trends.After age calibration,the incidence of ASR China and mortality of ASR China showed a decreasing trend(APC=-5.3,P=0.2;APC=-12.9,P=0.1),the trends were not statistically significant.Conclusion Although the incidence and mortality rate of cervical cancer in Gansu province have a decreasing trend,which poses a serious threat to the life and health of middle-aged and elderly women.Health education of cervical cancer prevention knowledge should be carried out actively,and healthy lifestyle should be advocated,so as to realize the effective prevention and control of cervical cancer.