羟苯磺酸钙对肾移植术后早期肾功能恢复的临床观察

Clinical observation on the calcium dobesilate in the recovery of early graft function after renal transplantation

目的探讨羟苯磺酸钙对肾移植术后早期移植肾功能恢复的效果。方法选取2018年1月—2019年1月于我院接受肾移植手术的患者60例。分为治疗组与对照组,治疗组于术后1月口服羟苯磺酸钙500 mg,每日1次。对照组未口服羟苯磺酸钙。比较两组术后尿量,血肌酐水平,内生肌酐清除率,B超检查移植肾动脉血流阻力指数及血肌酐下降至120μmol/L的时间。结果口服羟苯磺酸钙组患者术后尿量、内生肌酐清除率高于对照组,血肌酐水平、肾动脉血流阻力指数及血肌酐下降至200μmol/L所需时间低于对照组。结论羟苯磺酸钙用于肾移植术后早期患者安全且有助于移植肾功能恢复。

Objective To investigate the effects of calcium dobesilate in the recovery of early graft function after renal transplantation.Methods A total number of 60 patients who received renal transplantation in our department during January 1 st,2018 to January 1 st,2019 were enrolled.The patients were randomly divided into treatment group who were treated with 500 mg calcium dobesilate,QD for 1 month and control group who were not treated with calcium dobesilate in the same period.Urine volume after transplantation,level of serum creatinine(Scr),endogenous creatinine clearance(Ccr),blood flow resistanceindexes(RI)of renal graft artery under Doppler Ultrasonic and the time required for serum creatinine to decrease under 120μmol/L were compared.Results The urine volume after transplantation and CCr in treatment group were significantly higher than those in control group,SCr,blood flow RI and the time required for serum creatinine to decrease under 120μmol/L in treatment group were significantly less than those in control group.Conclusion Administration of calcium dobesilate in renal recipient is safe and effective for the recovery of early graft function after renal transplantation.