错误折叠蛋白与子痫前期相关研究进展

Advances in Research on Misfolded Protein and Preeclampsia

子痫前期(pre-eclampsia,PE)是一种全身性异质性妊娠期并发症,具体发病机制尚不明确,目前仍缺乏准确可靠的预测、诊断及有效的治疗方法。已知错误折叠蛋白是内质网氧化应激的产物,且错误折叠蛋白与许多人类疾病的发生、发展相关。近年来,有学者发现在PE孕妇的胎盘、血液及尿液中存在错误折叠蛋白,而且PE患者体内的错误折叠蛋白具有嗜刚果红的特性,可以使用刚果红(Congo red,CR)染色检测PE患者尿液,若刚果红点(Congo red dot,CRD)试纸的测试结果呈阳性,则患者可能在未来14 d内表现出PE相关症状,错误折叠蛋白或许可以作为预测PE的生物学标志物。

Preeclampsia is a systemic heterogeneous pregnancy complication,its specific pathogenesis is not clear,and there is still a lack of accurate and reliable prediction,diagnosis and effective treatment.It is known that misfolded proteins are the product of oxidative stress in the endoplasmic reticulum,and that misfolded proteins are associated with the occurrence and development of many human diseases.Recently,some scholars have found that there are misfolded proteins in placenta,blood and urine of preeclampsia pregnant women,and the misfolded protein in preeclampsia patients has the property of congophilia.The misfolded protein in the urine of preeclampsia patients can be detected by Congo red(CR)staining.If the test result of Congo red dot(CRD)test paper is positive,it may show preeclampsia-related symptoms within the next 14 days,and the misfolded protein may be used as a biomarker for predicting preeclampsia.