生物复合材料促进子宫内膜再生的研究进展

Research Advance of Biocomposite Materials in Promoting Endometrial Regeneration

宫腔粘连(intrauterine adhesion,IUA)是由子宫内膜损伤引起的纤维化修复障碍,并可能伴有月经异常并导致不孕。目前主流的临床治疗存在不同程度的局限性,如手术造成机械损伤和高炎症状态可能会进一步加重纤维化严重程度和带来不良妊娠结局,还有局部药物治疗和干细胞治疗存在低滞留率,导致促子宫内膜再生效果不佳。组织工程促进子宫内膜再生是一种新颖而有前景的思路,利用生物相容性材料作为载体将药物或干细胞等递呈到子宫腔中缓慢释放获得良好的治疗效果。其中,生物复合材料在治疗IUA方面的报道较少,但效果显著。现对生物复合材料这个组织工程方案治疗促进子宫内膜再生进行综述,以供参考。

Intrauterine adhesion(IUA)is a fibrosis repair disorder caused by endometrial injury,and may be accompanied by menstrual abnormalities and lead to infertility.The current mainstream clinical treatments have varying degrees of limitations.For example,mechanical damage and high inflammatory conditions caused by surgery may further aggravate the severity of fibrosis and bring adverse pregnancy outcomes.And there are also low retention rates for local drug treatment and stem cell therapy leading to poor effect of promoting endometrial regeneration.Tissue engineering to promote endometrial regeneration is a novel and promising idea that has been widely studied.The biocompatible materials as a carrier to deliver drugs or stem cells into the uterine cavity which are released slowly have good therapeutic effects.Among them,there are few reports of biocomposites in the treatment of IUA,but the effect is significant.Now,biocomposites using by the tissue engineering methods to promote endometrial regeneration will be reviewed as follow.