子宫腺肌病对子宫内膜癌的作用及相关机制的研究进展

Research Progress on the Effect of Adenomyosis on Endometrial Cancer and Related Mechanisms

子宫内膜癌是最常见的妇科恶性肿瘤之一,子宫腺肌病亦是常见的良性妇科疾病,均病因不明。两者既是两种独立的妇科疾病,又存在着错综复杂的联系。从流行病学以及临床病理特征来看,子宫腺肌病可能是子宫内膜癌发生的危险因素,但同时又是抑制子宫内膜癌进展的保护性因素。在疾病发生发展中,两者在分子信号通路、雌激素及其受体作用以及错配修复基因缺陷等方面存在着共同机制,并且因子宫腺肌病自身特征对子宫内膜癌产生了分子及机械阻断作用,阻碍了子宫内膜癌的进展。明确两者的相互关系,探究其潜在机制,能够为子宫内膜癌和子宫腺肌病的发病机制研究提供新的思路和方向,有助于子宫内膜癌和子宫腺肌病的临床精准诊疗及随访,提高疾病诊治效果。

Endometrial cancer is one of the most common gynecological malignancies,and adenomyosis is also a common benign gynecological disease,with unknown etiology.Adenomyosis and endometrial cancer are not only two independent gynecological diseases,but also have intricate connections.From the epidemiological and clinicopathological characteristics,adenomyosis may be a risk factor for endometrial cancer,but it is also a protective factor to inhibit the progression of endometrial cancer.From the pathogenesis,the two disease have common mechanisms on molecular signaling pathways,effects of estrogen and its receptors,and mismatch repair gene deficiency,and because of the molecular and mechanical blocking effects of adenomyosis on endometrial cancer,the progression of endometrial cancer is hindered.Clarifying the relationship between the two and the corresponding mechanism will contribute to the accurate clinical diagnosis and follow-up of endometrial cancer and adenomyosis,and improve the effect of diagnosis and treatment.