茵栀黄口服液联合宝乐安治疗新生儿病理性黄疸65例临床观察

Clinical observation on 65 cases of neonatal pathological jaundice treated by Yinzhihuang Koufuye(茵栀黄口服液)combined with Baole’an

目的观察茵栀黄口服液联合宝乐安治疗新生儿病理性黄疸的临床疗效。方法选取2018年2月至2019年2月兰州市妇幼保健院新生儿科收治的新生儿病理性黄疸患儿130例,采用抛硬币法将患儿随机分为对照组和治疗组,各65例。2组在新生儿病理性黄疸常规治疗的基础上,对照组使用茵栀黄口服液治疗,治疗组选在对照组治疗方法的基础上联合宝乐安治疗,2组均连续治疗7 d后,比较2组治疗前后血清总胆红素(TBIL)水平、黄疸消退时间及临床疗效。结果治疗前,2组血清TBIL水平比较,差异无统计学意义(P>0.05),具有可比性。治疗后,2组血清TBIL水平均显著下降,与同组治疗前比较,差异均有统计学意义(P<0.01),且治疗组下降更显著,与对照组治疗后比较,差异有统计学意义(P<0.05)。2组黄疸消退时间比较,差异有统计学意义(P<0.05)。对照组总有效率为81.5%(53/65),治疗组为96.9%(63/65),2组比较,差异有统计学意义(P<0.05)。结论茵栀黄口服液联合宝乐安治疗新生儿病理性黄疸,能明显降低患儿血清TBIL水平,缩短黄疸消退时间,疗效显著,值得临床推广应用。

Objective To observe the clinical efficacy of Yinzhihuang Koufuye(茵栀黄口服液)combined with Baole’an in the treatment of neonatal pathological jaundice.Methods From February 2018 to February 2019,130 cases of neonatal pathological jaundice admitted into pediatrics department of Lanzhou Maternity and Child Health Hospital were chosen and randomly divided into control group and treatment group according to flipping a coin method,with 65 cases in each group.On the basis of routine treatment of neonatal pathological jaundice,the control group was treated with Yinzhihuang Koufuye,and the treatment group was treated with Yinzhihuang Koufuye combined with Baole’an.After continuous treatment for 7 days,serum total bilirubin(TBIL)level before and after treatment,subsidence time of jaundice and clinical efficacy were compared between the 2 groups.Results Before treatment,there was no statistical significant difference in serum TBIL levels between the 2 groups(P>0.05),and they were comparable.After treatment,the serum TBIL levels of the 2 groups significantly decreased,and the differences were statistically significant compared with those before treatment in the same group(P<0.01),and the decrease in the treatment group was more significant,and the difference was statistically significant compared with that in the control group after treatment(P<0.05).There was statistically significant difference in jaundice subsidence time between the 2 groups(P<0.05).The total effective rate was 81.5%(53/65)in the control group and 96.9%(63/65)in the treatment group,and the difference was statistically significant between the 2 groups(P<0.05).Conclusion It can markedly decrease serum TBIL level of children patients and shorten subsidence time of jaundice with marked efficacy to use Yinzhihuang Koufuye combined with Baole’an in the treatment of neonatal pathological jaundice,which deserves clinical promotion and application.