金荞麦胶囊对轻中度哮喘急性发作期患者肺通气功能及EOS、IgE水平的影响

Effect of Jinqiaomai Capsules on the pulmonary ventilation function and the EOS,IgE levels in the patients with mild to moderate asthma during its acute attack

目的观察金荞麦胶囊对轻中度哮喘急性发作期患者肺通气功能及EOS、IgE水平的影响。方法将72例轻中度哮喘急性发作期患者随机分为2组,对照组36例给予西医常规治疗,观察组36例在对照组基础上给予金荞麦胶囊口服治疗,连续治疗1周,评估2组临床疗效,并比较2组治疗前后圣乔治呼吸问卷积分(呼吸症状积分、活动受限积分、疾病影响积分)、肺通气功能[肺活量(FVC)、第1秒用力呼气量(FEV1、最大呼气流量(PEF)]、免疫球蛋白E(IgE)及嗜酸粒细胞(EOS)的改善状况。结果观察组治疗后总有效率91.7%,显著高于对照组72.2%(P<0.05);2组治疗后呼吸症状积分、活动受限积分、疾病影响积分均显著降低(P<0.05),且观察组降低程度较对照组更明显(P<0.05);2组治疗后FVC、FEV1、PEF水平均显著升高(P<0.05),且观察组升高程度较对照组更明显(P<0.05);2组治疗后血清EOS、IgE水平均显著降低(P<0.05),且观察组降低程度较对照组更明显(P<0.05)。结论金荞麦胶囊能够显著降低哮喘急性发作期患者血清EOS和IgE水平,减轻呼吸道炎症反应,提高患者肺通气功能,改善患者临床症状,值得临床推广。

Objective To observe the effect of Jinqiaomai Capsules on the lung ventilation function and the levels of EOS and IgE in patients with mild to moderate asthma during its acute attack.Methods Seventy-two patients with mild to moderate asthma at the acute attack stage were randomly divided into 2 groups.The 36 patients in the control group were given the conventional western medicine treatment,and the 36 patients in the observation group were treated with Jinqiaomai Capsules on the basis of the control group.The treatment was continued for 1 week.The clinical efficacy of the two groups was evaluated,and the scores of St.George's Respiratory Questionnaire(the respiratory symptom score,the activity restriction score,and the disease impact score),the pulmonary ventilation function[vital capacity(FVC),forced expiratory volume in the first second(FEV1,maximum expiratory flow(PEF)],and the improvement of immunoglobulin E(IgE)and eosinophils(EOS)were compared between the two groups before and after the treatment.Results The total effective rate in the observation group was 91.7%after the treatment,which was significantly higher than 72.2%in the control group(P<0.05).The scores of the respiratory symptoms,the activity limitation,and the disease impact in the two groups were significantly reduced after the treatment(P<0.05),and the decrease degree in the observation group was more significant than that of the control group(P<0.05).The levels of FVC,FEV1S and PEF in the two groups were all increased significantly after the treatment(P<0.05),and the increase degree in the observation group was more significant than that of the control group(P<0.05).After the treatment in the 2 groups,the serum EOS and IgE levels were both significantly reduced(P<0.05),and the decrease degree in the observation group was more significant than that in the control group(P<0.05).Conclusion Jinqiaomai Capsules can significantly reduce the serum EOS and IgE levels in the patients with acute asthma attack,reduce the respiratory tract inflammation,improve the patients5 lung ventilation function,and improve the patients5 clinical symptoms,which is worthy of clinical promotion.