康柏西普玻璃体注射后行复合式小梁切除术对新生血管性青光眼的近远期疗效观察

Observation of the Short-term and Long-term Effect of Compound Trabeculectomy after Intravitreal Injection of Conbercept on Neovascular Glaucoma Patients

目的:观察康柏西普玻璃体注射后行复合式小梁切除术对新生血管性青光眼(NVG)患者的近远期疗效。方法:将平顶山市第一人民医院收治的67例NVG患者按照入院先后顺序随机分为观察组与对照组,其中观察组35例(35眼)、对照组32例(32眼)。对照组患者实施复合式小梁切除术治疗,观察组患者在给予康柏西普玻璃体注射后行复合式小梁切除术治疗。记录两组患者虹膜表面新生血管消退时间及术后并发症发生率,比较两组患者治疗前、治疗后1月、6月眼压水平,并于治疗后6个月比较两组患者视力情况及虹膜新生血管复发情况。结果:观察组患者消退时间为(3.88±1.09)d,对照组患者消退时间为(4.52±1.14)d,观察组低于对照组(P<0.05);观察组患者术后并发症1例发生率低于对照组5例,差异无统计学意义(P>0.05),且经对症处理后均好转;治疗后1月、6月两组患者眼压水平较治疗前下降明显,且观察组低于对照组(P<0.05);治疗后6月,两组患者视力水平较治疗前提高,且观察组高于对照组(P<0.05);治疗后6个月,观察组复发1例,对照组复发7例,观察组低于对照组(P<0.05)。结论:康柏西普玻璃体注射后行复合式小梁切除术治疗NVG,可有效降低患者眼压,恢复患者视力,预防复发。

Objective:To observe the short-term and long-term effects of compound trabeculectomy after vitreous injection of conbercept on neovascular glaucoma(NVG)patients.Methods:The 67 NVG patients admitted to Pingdingshan First People's Hospital were randomly divided into observation group and control group according to the order of admission,including 35 cases(35 eyes)in the observation group and 32 cases(32 eyes)in the control group.The patients in the control group were treated with compound trabeculectomy,and the patients in the observation group were treated with compound trabeculectomy after intravitreal injection of conbercept.The time of neovascularization on the surface of the iris and the incidence of postoperative complications were recorded in the two groups of patients.The intraocular pressure levels of the two groups were compared before treatment,1 month and 6 months after treatment,and the visual acuity and iris neovascularization recurrence of the two groups were compared 6 months after treatment.Results:The regression time of patients in the observation group was(3.88±1.09)days,and the time of patients in the control group was(4.52±1.14)days,which was lower in the observation group than in the control group(P<0.05);the incidence of postoperative complications in the observation group(1 case)was lower than that of the control group(5 cases),but the difference was not statistically significant(P>0.05),and all improved after symptomatic treatment;the intraocular pressure levels of the two groups were significantly lower than before treatment at 1 month and 6 months after treatment,the observation group was lower than the control group(P<0.05);6 months after treatment,the visual acuity of the two groups was higher than before treatment,and the observation group was higher than the control group(P<0.05);6 months after treatment,1 case recurred in the observation group,7 cases recurred in the control group,the observation group was lower than the control group(P<0.05).Conclusion:Compound trabeculectomy after vitreous injection of conbercept for the treatment of NVG can effectively reduce the intraocular pressure of the patient,restore the patient's vision,and prevent recurrence.