冬病夏治敷贴疗法联合孟鲁司特、噻托溴铵治疗ACOS的疗效

Efficacy of plastering therapy based on the theory of winter disease cured in summer combined with montelukast and tiotropium bromide in the treatment of ACOS

目的探究冬病夏治敷贴疗法联合孟鲁司特、噻托溴铵治疗哮喘-慢阻肺重叠综合征(ACOS)的疗效。方法选取2017年1—12月本院收治的86例ACOS患者为研究对象,按随机数表法分为对照组和观察组两组,每组各43例。对照组患者应用孟鲁司特、噻托溴铵治疗,观察组患者在对照组基础上实施冬病夏治敷贴疗法。比较2年后两组患者疗效,比较治疗前、治疗2年后两组患者中医症候积分、病情控制程度[哮喘控制测试评分(ACT)、慢性阻塞性肺疾病患者自我评估测试(CAT)]、肺功能[第1 s用力呼气容积(FEV1)、肺活量(FVC)、FEV1/FVC]。结果治疗2年后,观察组患者总体疗效高于对照组,差异有统计学意义(P<0.05),但两组总有效率比较,差异有统计学意义(P>0.05);两组中医症候积分均较治疗前下降,且观察组中医症候积分低于对照组,差异有统计学意义(P<0.05);两组ACT评分较治疗前上升,且观察组ACT评分高于对照组,差异均有统计学意义(P<0.05);两组CAT评分均较治疗前降低,且观察组CAT评分低于对照组,差异均有统计学意义(P<0.05);两组FEV1、FVC、FEV1/FVC均较治疗前上升,且观察组各指标均高于对照组,差异均有统计学意义(P<0.05)。结论冬病夏治敷贴疗法联合孟鲁司特、噻托溴铵治疗ACOS有助于改善总体疗效,能有效减轻患者症状,控制患者病情,并有利于改善肺功能。

Objective Toinvestigate the efficacy of application therapy based on the theory of winter disease cured in summercombined with monlukast and tiotropium bromide in the treatment of asthma COPD overlap syndrome(ACOS).Methods A total of 86 patients with ACOS admitted to our hospital from January 2017 to December 2017 were selected as the research object and divided into control group and observation group according to random number table method,with 43 cases in each group.Control group was treated with montelukast and tiotropium bromide,and observation group was treated with plastering therapy based on the theory of winter disease cured in summeron the basis of control group.The efficacy of the two groups was compared after 2 years.The TCM syndrome score,disease control degree[asthma control test score(ACT),chronic obstructive pulmonary disease self-assessment test(CAT)]and lung function The forced expiratory volume in 1S(FEV1),forced vital capacity(FVC),(FEV1/FVC)were compared between the two groups before treatmentand 2 years after treatment.Results After 2 years of treatment,the overall efficacy of the observation group was higher than that of the control group,the difference was statistically significant(P<0.05),the difference of total effective rate between the two groups was statistically significant(P<0.05).The scores of TCM symptoms in both groups decreased compared with those before treatment,and the scores of TCM symptoms in the observation group were lower than that in the control group,with statistical significance(P<0.05).ACT scores of the two groups were increased compared with those before treatment,and ACT scores of the observation group were higher than that of the control group,with statistical significance(P<0.05).CAT scores in both groups were lower than those before treatment,and CAT scores in observation group were lower than control group,the differences were statistically significant(P<0.05).FEV1,FVC and FEV1/FVC increased in both groups compared with those before treatment,and each of the indexes in the observation group was higher than that in the control group,with statistical significance(P<0.05).Conclusions Application therapy based on the theory of winter disease cured in summer combined with montelukast and tiotropium bromide in the treatment of ACOS is helpful to improve the overall efficacy,effectively reduce the symptoms of patients,control the condition of patient,and improve the lung function.