超声评估从事农业活动40~60岁女性左心室结构和功能与颈动脉硬化进展的关系

Evaluate the relationship between left ventricular structure/functions and progress of arterial stiffnes in women aged from 40 to 60 years old those engage in agricultural activities using ultrasound

目的探讨从事农业活动大龄女性的左心室结构和功能与颈动脉硬化进展的关系。方法招募2017年3月—2019年3月150名从事农业活动40~60岁女性受试者,按照年龄分为中年组(40~49岁)和老年组(50岁以上),采用自动脉搏波速度测定仪测定颈动脉-股动脉脉搏波速度(cf-PWV),使用超声扫描仪进行经胸超声心动图检查,计算心脏超声参数。结果Pearson的相关分析显示,cf-PWV与RWT、LVED、LVES、E/A、e'/a'、E/e'、GCS、左室整体圆周收缩峰值应变(GRS)、ApexRot和LV Twist都具有相关性(P<0.05),但与LVMI、LVEF、GLS和BaseRot无统计学相关性(P>0.05)。多变量线性回归显示,当调整年龄、体重指数(BMI)、收缩压、脉压和心率时,cf-PWV仅与RWT、GCS、ApexRot和LV Twist有显著统计学相关性(P<0.05)。结论在从事农业活动大龄女性中,主动脉硬化程度增加与LV扭转增加相关,但与LV心肌的舒张功能和全局纵向应变无显著的相关性。

Objective The aim of this study was to investigate the relationship between left ventricular structure and function and progression of carotid atherosclerosis in older women engaged in agricultural activities.Methods From March 2017 to March 2019,150 female subjects aged 40~60 years those engaged in agricultural activities were recruited and divided into middle-aged group(40~49 years)and the elderly group(elder than 50 years old)according to their ages.The carotid femoral pulse wave velocity(cf-PWV)was measured by automatic pulse wave velocity meter,and the echocardiography parameters were calculated by transthoracic echocardiography.Results Pearson correlation analysis showed that cf-PWV was correlated with RWT,LVED,LVES,E/A,e'/a',E/e',GCS,global peak circumferential strain(GRS),apexrot and LV twist(P<0.05),but not correlated with LVMI,LVEF,GLS and BaseRot(P>0.05).Multivariate linear regression-showed that cf PWV was only significantly correlated with RWT,GCS,ApexRot and LV twist when adjusting for age,body mass index(BMI),systolic blood pressure,pulse pressure and heart rate.Conclusions Among the elder women those engaged in agricultural activities,the increase degree of carotid atherosclerosis is correlated to LV torsion increases,however,there was no significant correlation to diastolic function of LV myocardium and global longitudinal strain.