美沙拉嗪相关红棕色尿色异常一例

Mesalamine-associated red-brown urine discoloration:a case report

美沙拉嗪(5-氨基水杨酸)用于治疗溃疡性结肠炎、轻度克罗恩病,其多以代谢物N-乙酰基-5-氨基水杨酸的形式通过肾脏快速代谢,少见肾损害及血尿,但在部分患者中发现口服后出现红棕色尿,此现象与其代谢物与水中清洁剂含有的残余次氯酸盐结合有关。本文报道了1例美沙拉嗪相关尿色异常并进行文献复习。

Mesalamine(5-aminosalicylic acid,5-ASA)is used for ulcerative colitis,mild Crohn′s disease.The orally taken mesalamine is excreted primarily as N-acetyl-5-aminosalicylic acid(N-acetyl-5-ASA)via urine,renal damage and hematuria are rare.However,red-brown urine discoloration has been noted by some patients,which is associated with the reaction between N-acetyl-5-ASA and remaining hypochlorite in the disinfectant-containing water.This article reports a case of mesalamine-associated red-brown urine discoloration and reviews related literatures.