伏立康唑致结膜水肿不良反应1例报道及文献分析

Voriconazole Induced Conjunctival Edema Adverse Reactions:a Case Report and Literature Analysis

目的分析伏立康唑致结膜水肿不良反应的临床特点、处置措施及预后。方法报道1例伏立康唑致结膜水肿的不良反应,并检索建库至2020年12月国内外公开发表的伏立康唑致水肿不良反应的文献,提取不良反应的临床特征、处置措施及预后等信息进行总结。结果中文数据库及Pubmed数据库共检索到文献110篇,逐一进行筛选,共收集到伏立康唑引起水肿不良反应的文献7篇,包括3篇案例报道及4篇临床研究,总计病例8例。水肿的不良反应表现为嘴唇和舌头肿胀、胸腔腹腔积液、体重增加、踝部水肿等,大部分病例停用伏立康唑后水肿消退,预后良好。结论临床使用伏立康唑时需注意其致水肿的不良反应,症状出现后及时停药,以确保用药安全性。

Objective To analyze the clinical characteristics,treatment measures and prognosis of conjunctival edema adverse reactions caused by voriconazole.Methods This paper reported a case of conjunctival edema adverse reactions caused by voriconazole,and searched the literature of edema adverse reaction caused by voriconazole published at chinese database and PubMed database from the establishment of the database to December 2020,extracted and summarized the information of the clinical characteristics,treatment measures and prognosis.Results A total of 110 litertatures were retrieved from chinese database and PubMed database,7 literatures with 8 cases were collected,including 3 case reports and 4 clinical studies.The clinical manifestations included swelling of lips and tongue,pleural and peritoneal effusion,weight gain and ankle edema.Most of the reactions disappeared after withdrawal of voriconazole,and the prognosis was well.Conclusion When using voriconazole in clinical,it is necessary to pay attention to the edema adverse reactions,and timely withdrawl should be taken if symptoms appear,so as to ensure the safety use.