IL-35在自身免疫性疾病中的机制研究

Study on the mechanism of IL-35 in autoimmune diseases

IL-35作为一种抗炎因子,由p35亚基和EBI3亚基组成。IL-35在许多疾病中发挥着重要作用,但很多作用机制尚未明确。近几年,人们发现IL-35在自身免疫性疾病中发挥着重要的免疫调节功能,如类风湿性关节炎、炎症性肠病、银屑病、特发性炎症性肌病、系统性红斑狼疮、多发性硬化症、Ⅰ型糖尿病、天疱疮和原发性胆汁性肝硬化等。本篇综述总结了IL-35在以上多种自身免疫性疾病中的作用机制研究进展。

As an anti-inflammatory factor,Interleukin 35(IL-35)is composed of p35 subunit and EBI3 subunit.IL-35 plays an important role in many diseases,but many mechanisms are not clear.In recent years,it has been found that IL-35 plays an important immunomodulatory role in autoimmune diseases,such as rheumatoid arthritis,inflammatory bowel disease,psoriasis,idiopathic inflammatory myopathy,systemic lupus erythematosus,multiple sclerosis,type I diabetes,pemphigus and primary biliary cirrhosis,etc.This review summarizes the research progress of the mechanism of IL-35 in the above autoimmune diseases.