肠道菌群与川崎病关系研究进展

Relationship between gut microbiota and Kawasaki disease

川崎病是一种以全身性血管炎为病理基础的疾病,已成为儿童获得性心脏病的最常见疾病,但其病因和发病机制仍不明确。肠道菌群稳态对机体免疫系统成熟及免疫调节有重要作用,肠道菌群紊乱参与儿童多种炎症免疫性疾病。研究发现,川崎病患儿存在肠道菌群组成的改变,肠道菌群紊乱与川崎病的发生发展有关,可能通过肠道黏膜屏障功能障碍、免疫炎症反应、氧化应激、代谢产物作用等多种机制影响免疫系统的正常功能。该文将对肠道菌群与川崎病关系的研究进展进行综述。

Kawasaki disease is a disease based on systemic vasculitis,which has become the most common disease in children with acquired heart disease,but its etiology and pathogenesis remain unclear.The homeostasis of the gut microbiota plays an important role in the maturation of the body′s immune system and immune regulation.The disorder of the gut microbiota is involved in a variety of inflammatory and immune diseases in children.Studies have found that there are changes in the composition of gut microbiota in children with Kawasaki disease.Gut microbiota disorders are related to the occurrence and development of Kawasaki disease,with the immune system function affected.Various mechanisms such as intestinal mucosal barrier dysfunction,immune inflammation,oxidative stress and metabolite effects promote the pathogenesis of Kawasaki disease.This article reviews the research on the relationship between gut microbiota and Kawasaki disease.