柯萨奇病毒A组10型相关研究进展

Progress of coxsackievirus A10

手足口病(hand,foot and mouth disease,HFMD)是我国5岁以下儿童常见的丙类传染病,由多种肠道病毒引起。近年研究发现柯萨奇病毒A组10型(coxsackievirus A10,CVA10)逐渐成为HFMD主要病原体之一,其感染呈上升趋势,与肠道病毒71型(enterovirus 71,EV71)、柯萨奇A组16型(coxsackievirus A16,CVA16)、柯萨奇A组6型(coxsackievirus A6,CVA6)呈共循环流行。CVA10细胞受体为含环状结构跨膜蛋白1(recombinant kringle containing transmembrane protein 1,KRM1),特异性中和抗体命名为2G8,相关动物模型中的疫苗主要为灭活疫苗及病毒样颗粒疫苗。该文就CVA10的细胞受体、中和抗体、疫苗与动物模型研究等方面做出阐述,为HFMD的防控提供一定思路。

Hand,foot and mouth disease(HFMD)is a common class C infectious disease for children under 5 years of age in our country,which pathogens are multiple enteroviruses.Recent studies have found that coxsackievirus A10(CVA10)has become one of the main pathogens of HFMD gradually,and its infection is on the rise.Moreover,enterovirus 71(EV71),coxsackievirus A16(CVA16),coxsackievirus A6(CVA6),and CVA10 co-circulate has appeared.The CVA10 cell receptor is recombinant kringle containing transmembrane protein 1(KRM1),and the specific neutralizing antibody is named 2G8.The vaccines in related animal models are inactivated vaccines and virus-like particle vaccines.This paper reviews on aspects of cell receptors,neutralizing antibodies,vaccines researches and animal models about CVA10,providing some ideas for the prevention and control of HFMD.