丹红注射液辅助西药对脑血栓患者氧化应激及血管内皮功能的影响

Effect of Danhong Injection Assisting Western Medicine in Oxidative Stress and Vascular Endothelial Function in Patients with Cerebral Thrombosis

目的:研究丹红注射液辅助西药对脑血栓患者氧化应激及血管内皮功能的影响。方法:选择2018年1月2019年12月于我院诊治的90例脑血栓患者,根据治疗方法将其分为两组。对照组西药治疗,给予前列地尔注射液、依达拉奉注射液和阿司匹林肠溶片;观察组在对照组治疗基础上,联用丹红注射液,两组均治疗14 d。比较两组的髓过氧化物酶(Myeloperoxidase, MPO)、超氧化歧化酶(Superoxide dismutase, SOD)、脂质过氧化物(Lipid peroxide, LPO)、丙二醛(Malondialdehyde, MDA)、D二聚体(D-Dimer, DD)及超敏C反应蛋白(High-sensitivity C-reactive protein, hs-CRP)水平,一氧化氮(Nitric oxide,NO)和内皮素-1(endothelin-1,ET-1)水平及认知功能评分。结果:观察组脑血栓患者的有效率明显高于对照组(P<0.05);治疗后,两组血清SOD、NO水平均明显升高(P<0.05),MPO、MDA、LPO、D-D、hs-CRP和ET-1水平均明显降低(P<0.05),且观察组上述指标的变化水平明显优于对照组(P<0.05);治疗后,两组的NIHSS评分明显降低(P<0.05),且观察组更低(P<0.05)。结论:丹红注射液辅助西药能改善脑血栓的神经功能和血管内皮功能,提高疗效,减轻患者的神经功能缺损程度,其作用机制可能与抗自由基、减轻炎症反应和抑制脂质过氧化反应等有关。

Objective:To study the effect of Danhong injection assisting western medicine in oxidative stress and vascular endothelial function in patients with cerebral thrombosis.Methods:A total of 90 patients with cerebral thrombosis,who were treated in the First Affiliated Hospital of the Fourth Military Medical University from January 2018 to December 2019,were selected and divided into two groups according to treatment methods.The control group was treated with western medicine(alprostadil injection,edaravone injection and aspirin enteric-coated tablets);the observation group was treated with Danhong injection on the basis of the control group’s therapy,and both groups were treated for 14 days.The levels of myeloperoxidase(MPO),superoxide dismutase(SO),lipid peroxide(LPO),malondialdehyde(MDA),D-Dimer(DD)and high sensitivity C-reactive protein(hs CRP),nitric oxide(NO)and endothelin-1(ET-1)levels,and cognitive function scorewere were compared between the two groups.Results:The effective rate of the observation group was significantly higher than that of the control group(P<0.05).After treatment,the levels of serum SOD and NO in the two groups were significantly increased(P<0.05),and the levels of MPO,MDA,LPO,DD,hs-CRP and ET-1 were significantly decreased(P<0.05),and the levels of the above indicators of the observation group was significantly better than those of the control group(P<0.05).After treatment,NIHSS scores of the two groups were significantly decreased(P<0.05),and the observation group was lower(P<0.05).Conclusion:Danhong injection assisting western medicine can improve the neurological function and vascular endothelial function of cerebral thrombosis,improve the curative effect,and reduce the degree of neurological deficit in the patients.Its mechanism may be related to anti free radical,reducing inflammatory reaction and inhibiting lipid peroxidation.