阿立哌唑结合心理行为疗法治疗儿童抽动障碍的疗效及对血流动力学的影响

Effect of Aripiprazole Combine with Psycho Behavioral Therapy in the Treatment of Children with tic Disorder and Its Influence on Hemodynamics

目的:研究阿立哌唑结合心理行为疗法治疗儿童抽动障碍的疗效及对血流动力学的影响.方法:选取2018年1月~2020年1月我院收治的抽动障碍患儿80例,将所有患儿以随机数字表法分为对照组与研究组,每组各40例.对照组给予氟哌啶醇结合心理行为疗法治疗,研究组给予阿立哌唑结合心理行为疗法治疗,疗程均为10周.比较两组临床疗效,治疗前后患儿抽动障碍情况、血流动力学指标变化以及不良反应发生情况.结果:研究组总有效率为95.00%,高于对照组的77.50%(P< 0.05).治疗后研究组发声性抽调、运动性抽动、行为以及运动不宁评分分别为(2.81±1.07)分、(1.94±0.45)分、(1.16±0.44)分、(0.82± 0.50)分,均明显低于对照组的(4.71±0.73)分、(2.77±0.38)分、(1.57±0.39)分、(1.22± 0.43)分(P<0.05).治疗前后两组心率(HR)、能量转换指数(MEC)、左心室机械效率(LME)以及心肌耗氧量(MVO)水平对比均无统计学差异(P>0.05).研究组不良反应发生率为7.50%,低于对照的25.00%(P< 0.05).结论:阿立哌唑结合心理行为疗法治疗儿童抽动障碍疗效显著,可有效改善患儿临床症状,对血流动力学影响较小,具有较好的安全性.

Objective:To study the effect of aripiprazole combine with psycho behavioral therapy in the treatment of children with tic disorder and its Influence on hemodynamics.Methods:80 children with tic disorder who were treated in our hospital from January2018 to January 2020 were selected,all patients were divided into study group and control group according to the random number table method,80 cases in each group.The control group was treated with haloperidol combined with psycho behavioral therapy,the study group was treated with aripiprazole combined with psycho behavioral therapy,the course of treatment was 10 weeks.The clinical effects of two groups,the situation of children with tic disorder and the change of hemodynamic index before and after treatment and the occurrence of adverse reaction were compared.Results:The total effective rate of the study group was 95.00%,which was higher than 77.50%of the control group(P<0.05).The voice scores,motor tic disorders,behavioral and motor restlessness scores in the study group after treatment were(2.8±1.07)points,(1.94±0.45)points,(1.16±0.44)points,(0.82±0.50)points respectively,which were significantly lower than(4.71±0.73)points,(2.77±0.38)points,(1.57±0.39)points,(1.22±0.43)points of the control group(P<0.05).There were no significant differences in heart rate(HR),energy conversion index(MEC),left ventricular mechanical efficiency(LME)and myocardial oxygen consumption(MVO)before and after treatment between the two groups(P>0.05).The incidence of adverse reactions in the study group was 7.50%,which was lower than 25.00%of the control group(P<0.05).Conclusion:The treatment of aripiprazole combine with psycho behavioral therapy on children with tic disorder has significant effect,can improve the clinical symptoms of children,it has little effect on hemodynamics,and has good safety.