小青龙汤加味联合盐酸左西替利嗪胶囊治疗鼻鼽的疗效及免疫功能探究

Study on the Curative Effect and Immune FFunction of Xiaoqinglong Decoction Combined with Levocetirizine Hydrochloride Capsule in the Treatment of Rhinitis

目的:探究小青龙汤加味联合盐酸左西替利嗪胶囊治疗鼻鼽的疗效及免疫功能.方法:选择2018年12月至2020年4月陕西省中医医院诊治的鼻鼽患者102例,按照随机的数字表法分为两组,研究组60例,给予小青龙汤加味联合盐酸左西替利嗪胶囊治疗;对照组62例,给予盐酸左西替利嗪胶囊治疗,两组均持续治疗28 d,对比两组治疗的有效率、治疗前后症候积分、免疫指标免疫球蛋白E(immunoglobulin E,IgE)、白介素(interleukin,IL)IL-4、IL-12、IL-17A、IL-35及不良反应的情况.结果:治疗前,两组的症候积分比较无差异(P>0.05),治疗28 d后,两组的症候积分均显著降低,且观察组显著低于对照组(P<0.05).治疗后观察组的总有效率为91.67%,显著高于对照组(75.81%,P<0.05).治疗前,两组的IgE、IL-4、IL-12、IL-17A、IL-35的水平对比无差异(P>0.05),治疗后28 d,两组IgE、IL-4、IL-17A水平均降低,IL-12、IL-35的水平升高,且研究组均优于对照组(P<0.05).治疗期间观察组不良反应的发生率为8.33%,与对照组对比无差异(11.29%,P>0.05).结论:小青龙汤加味联合盐酸左西替利嗪胶囊治疗鼻鼽,能够显著改善患者的症候,提高疗效,改善患者的免疫功能,同时有助于矫正体内免疫功能失衡,系可能是治疗鼻鼽的机制,同时不会增加不良反应.

Objective:To explore the efficacy and immune function of Xiaoqinglong decoction combined with levocetirizine hydrochloride capsules in the treatment of rhinitis.Methods:A total of 102 patients with nasal rhinitis diagnosed and treated in our hospital from December 2018 to April 2020 were selected.They were divided into two groups according to the random number table method,and 60 patients in the study group were given Xiaoqinglong decoction combined with levocetirizine hydrochloride capsule 62 cases in the control group were given levocetirizine hydrochloride capsules,and the two groups were treated continuously for 28 days,comparing the effectiveness of treatment,symptom score before and after treatment,immune indicators IgE,IL-4,IL-17A,IL-35 and the situation of adverse reactions.Results:After 28 days of treatment,the symptom scores of the two groups were significantly reduced,and the observation group was significantly lower(P<0.05).The total effective rate of the observation group after treatment was 91.67%,significantly higher than that of the control group(75.81%,P<0.05).Before treatment,there was no difference in the levels of IgE,IL-4,IL-12,IL-17A,and IL-35 between the two groups(P>0.05).28 days after treatment,IgE,IL-4,IL-17A in the two groups The average level decreased,the levels of IL-12 and IL-35 increased,and the study group was better(P<0.05).During the treatment period,the incidence of adverse reactions in the observation group was 8.33%,which was not different from that in the control group(11.29%,P>0.05).Conclusion:Xiaoqinglong decoction combined with levocetirizine hydrochloride capsules in the treatment of rhinitis can significantly improve the patient’s symptoms,improve the curative effect,improve the patient’s immune function,and correct the imbalance of immune function in the body,will increase adverse reactions.