多糖铁复合物胶囊在模拟人体环境下的降磷效果研究

Study on phosphorus-lowing effect of Iron-polysaccharide Complex Capsules in simulated gastric fluid in vitro

目的研究多糖铁复合物胶囊在模拟人体环境下的降磷效果。方法以磷结合率为考察指标,采用单因素试验和正交试验筛选多糖铁复合物胶囊在模拟人体环境下的降磷方法;并且采用磷钼蓝法,对多糖铁复合物胶囊和磷结合剂(氢氧化铝片、碳酸钙片、碳酸镧咀嚼片和司维拉姆片)降磷效果进行比较。结果多糖铁复合物胶囊在模拟人体环境下的最佳降磷条件是pH 3.0,水浴37℃,反应120 min。在相同条件和剂量下,多糖铁复合物胶囊降磷效果优于氢氧化铝片、碳酸镧咀嚼片(P<0.01)和碳酸钙片(P<0.05),但略差于司维拉姆片(P<0.01)。结论多糖铁复合物胶囊在模拟人体环境下可以显著降低磷酸盐含量。

Objective To analyze the phosphorus-lowing effect of Iron-polysaccharide Complex Capsules in simulated gastric fluid in vitro.Methods The phosphorus binding rate was used as the indicator,and single factor experiment and orthogonal experiment were used to select the method of reducing phosphorus of Iron-polysaccharide Complex Capsules in simulated gastric fluid in vitro.The phosphorus-lowing effect of Iron-polysaccharide Complex Capsules was compared with those of phosphorus binders(eg.Aluminium Hydroxide Tablets,Calcium Carbonate Tablets,Lanthanum Carbonate Chewable Tablets and Sevelamer Carbonate Tablets),using phosphomolybdenum blue method.Results The optimal phosphorus-lowing conditions of Iron-polysaccharide Complex Capsules in simulated gastric fluid in vitro were obtained as follows:pH at 3.0,water bath at 37℃,reaction for 120 min.Phosphorus-lowing effect of Iron-polysaccharide complex capsules was superior to Aluminium Hydroxide Tablets,Lanthanum Carbonate Chewable Tablets(P<0.01)and Calcium Carbonate Tablets(P<0.05),but slightly inferior to Sevelamer Carbonate Tablets(P<0.01),under the same conditions and dosage.Conclusion The experiment results showed that Iron-polysaccharide Complex Capsules can significantly reduce phosphate content in simulated gastric fluid in vitro.