针灸温通法联合米氮平治疗难治性抑郁症临床评价

Clinical Evaluation of Warm-Dredging Acupuncture Combined with Mirtazapine in the Treatment of Refractory Depression

目的探讨针灸温通法联合米氮平治疗难治性抑郁症的临床疗效。方法选取医院2018年3月至2020年2月收治的患者104例,按随机数字表法分为观察组和对照组,各52例。两组患者均予米氮平片口服,观察组患者加用针灸温通法治疗。结果观察组总有效率为88.46%,显著高于对照组的71.15%(P<0.05);治疗后,观察组患者各中医证候评分及皮质醇、三碘甲状腺原氨酸、促肾上腺皮质激素水平均显著低于对照组(P<0.05),认知功能筛查量表各项评分均显著高于对照组(P<0.05);观察组与对照组不良反应发生率相当(15.38%比9.62%,P>0.05)。结论针灸温通法联合米氮平治疗难治性抑郁症,能改善患者的中医证候、认知功能和神经内分泌相关指标。

Objective To investigate the clinical efficacy of warm-dredging acupuncture combined with mirtazapine in the treatment of refractory depression.Methods A total of 104 patients with refractory depression admitted to our hospital from March 2018 to February2020 were selected and divided into the observation group and the control group according to the random number table method,52 cases in each group.The patients in the two groups were treated with Mirtazapine Tablets,on this basis,the patients in the observation group were treated with warm-dredging acupuncture.Results The total effective rate of the observation group was 88.46%,which was significantly higher than 71.15%of the control group(P<0.05).After treatment,the traditional Chinese medicine(TCM)syndrome scores,the levels of cortisol(COR),triiodothyronine(T3)and adrenocorticotropic hormone(ACTH)in the observation group were significantly lower than those in the control group(P<0.05),and the scores of cognitive function screening scale(CASI)in the observation group were significantly higher than those in the control group(P<0.05).The incidence of adverse reactions in the observation group was similar to that in the control group(15.38%vs.9.62%,P>0.05).Conclusion Warm-dredging acupuncture combined with mirtazapine in the treatment of refractory depression can improve the TCM symptoms,cognitive function and neuroendocrine-related indexes of patients.