HIF-VEGF-Ang-2信号转导介导的滑膜血管新生在类风湿关节炎中的作用

The role of HIF-VEGF-Ang-2 signal transduction-mediated synovial angiogenesis in rheumatoid arthritis

类风湿关节炎(rheumatoid arthritis, RA)是一种以血管新生、炎性因子浸润和关节破坏为主要病理特征的自身免疫性疾病。血管新生推动RA的发展,在其发病机制中发挥重要作用。HIF (hypoxia-inducible factor)-VEGF(vascular endothelial growth factor)-Ang-2 (angiopoietin-2)信号转导是诱导滑膜血管新生的关键途径。靶向HIFVEGF-Ang-2信号转导抑制滑膜血管新生是一种有前景的RA治疗方法。本文对HIF-VEGF-Ang-2信号转导介导的滑膜血管新生在RA中的作用和机制进行综述,以期为RA的治疗提供新的靶点和策略。

Rheumatoid arthritis(RA)is an autoimmune disease with angiogenesis,inflammatory factor infiltration and joint destruction as the main pathological features.Angiogenesis promotes the development of RA and plays an important role in its pathogenesis.The hypoxia-inducible factor(HIF)-vascular endothelial growth factor(VEGF)-angiopoietin-2(Ang-2)signal transduction is a critical pathway to induce synovial angiogenesis.Targeting HIF-VEGF-Ang-2 signal transduction to inhibit synovial angiogenesis is a promising approach for RA treatment.This article reviews the role and mechanism of HIF-VEGF-Ang-2 signal transduction-mediated synovial angiogenesis in RA,in order to provide a new target and strategy for RA treatment.