微针应用后皮肤孔道形成与闭合的影响因素及评价方法

Influencing factors and evaluation methods of skin microchannels formation and closure after microneedles application

微针作为一种微创、安全和高效的新型经皮给药技术,受到越来越多的关注。微针在皮肤表面形成的孔道是该技术递送药物的前提和关键,但目前缺少对皮肤孔道的系统性评价。本文综述了有关微针致皮肤孔道形成与闭合的影响因素及评价方法,涉及微针几何参数、制备材料、药物、刺入参数、受试者皮肤差异和有无闭塞等方面因素,为微针应用的有效性和安全性提供参考和借鉴。

As a novel transdermal drug delivery technology of minimally invasive,safe and efficient,microneedles have received increasing attention.The microchannels formation by microneedles onto the skin is a prerequisite and key for microneedles to deliver drugs.However,there is still a lack of systematic evaluation in skin microchannels.This review summarized influencing factors and evaluation methods in microchannels formation and healing by microneedles,including geometric parameters,materials for preparation,drugs,penetration parameters,differences among the skin of subjects,and presence or absence of occlusion.This review provides reference for other scholars to further study the effectiveness and security of microneedle applications.