过敏性鼻炎患儿血清25(OH)D、特异性IgE水平与VAS评分的相关性

Correlation between serum 25(OH)D,specific IgE and VAS score in children with allergic rhinitis

目的探讨过敏性鼻炎(AR)患儿血清25-羟基维生素D[25(OH)D]、特异性免疫球蛋白E(IgE)水平与症状视觉模拟(VAS)评分之间的关系。方法选取AR患儿38例(AR组)、非AR患儿38例(非AR组)和健康体检儿童40名(正常对照组),检测所有对象血清25(OH)D及特异性IgE水平,同时对AR患儿进行VAS评估。采用受试者工作特征(ROC)曲线评估25(OH)D在判断中重度AR中的价值。结果AR组血清25(OH)D水平明显低于非AR组和正常对照组(P<0.05),血清特异性IgE水平均明显高于非AR组和正常对照组(P<0.05)。在AR患儿中,轻度组血清25(OH)D水平高于中重度组(P<0.05),血清特异性IgE水平低于中重度组(P<0.05)。相关性分析结果显示,AR患儿VAS评分与血清25(OH)D水平呈负相关(r=-0.637,P<0.001),与血清特异性IgE水平呈正相关(r=0.654,P<0.001)。ROC曲线分析结果显示,25(OH)D判断中重度AR的曲线下面积为0.862,最佳临界值为10.13 ng/mL,敏感性为81.3%,特异性为78.6%。结论血清25(OH)D、特异性IgE水平对AR患儿的辅助诊断及病情严重程度的判断有一定价值。

Objective To investigate the relationship between serum 25-hydroxyvitamin D[25(OH)D],specific immunoglobulin E(IgE)and visual analog scale(VAS)score in children with allergic rhinitis.Methods Serum 25(OH)D and specific IgE level were determined in 38 children with AR(AR group),38 children without AR(non-AR group)and 40 healthy children(healthy control group),and VAS was evaluated in all children with AR.Receiver operating characteristic(ROC)curve was used to evaluate the role of 25(OH)D in judging moderate or severe AR.Results The level of 25(OH)D in AR group was lower than those in non-AR group and healthy control group(P<0.05),and the level of specific IgE in AR group was higher than those in non-AR group and healthy control group(P<0.05).The level of 25(OH)D in mild group was higher than those in moderate and severe group(P<0.05),and the level of specific IgE was lower than those in moderate and severe group(P<0.05).Correlation analysis showed that VAS was negatively correlated with 25(OH)D(r=-0.637,P<0.001),and it had a positive correlation with specific IgE(r=0.654,P<0.001).ROC curve analysis showed that the area under the curve of 25(OH)D was 0.862,and the optimal cut-off value was 10.13 ng/mL,with the sensitivity of 81.3%and the specificity of 78.6%.Conclusions The level of 25(OH)D and specific IgE have certain value in the auxiliary diagnosis and judgment of the severity of child AR.