动物性食品中喹诺酮类药物残留检测方法研究进展

Research progress on determination methods of quinolone residues in animal food

喹诺酮类药物是广谱抗菌药,具有良好的生物利用度和耐受性,不仅对革兰氏阳性菌和阴性菌有杀菌作用,还具有抗真菌和抗病毒活性,因此在兽医临床上广泛应用于治疗畜禽动物养殖过程中的细菌性感染。随着食品安全和兽药残留问题越来越受到大众关注,加强对动物性食品中喹诺酮类药物残留的监测十分必要。本文对喹诺酮类药物残留的主要检测方法进行了综述,主要包括酶联免疫吸附测定法、高效液相色谱法、高效液相色谱-串联质谱法、毛细管电泳法、比色法等,通过分析各种方法的优缺点,对动物性食品中喹诺酮类药物残留检测技术进行了展望,旨在为残留监控提供参考方法。

Quinolones are broad-spectrum antibacterial drugs,excellent bioavailability and tolerance.They not only have a bactericidal effect on Gram-positive and Gram-negative bacteria,but also have antifungal and antiviral activity.Therefore,they are widely used in the treatment of bacterial infection in the process of livestock and poultry breeding in veterinary clinic.With food safety and veterinary drug residues getting more and more public attention,it is necessary to strengthen the monitoring of quinolones residues in animal food.This paper reviewed the main detection methods for quinolone drug residues,including enzyme-linked immunosorbent assay,high performance liquid chromatography,high performance liquid chromatography-tandem mass spectrometry,capillary electrophoresis,colorimetric method etc,analyzed the advantages and disadvantages of various methods,and prospected the detection technology of quinolone residues in animal food,aiming to provide a reference method for residue monitoring.