微小RNA与阿尔茨海默病

MiRNA and Alzheimer′s disease

阿尔茨海默病(Alzheimer′s disease,AD)是一种中枢神经系统退行性疾病。其发病隐匿,患者从开始有病理改变到出现临床症状往往经历数年甚至十余年的病程演变。一旦进入痴呆期,目前尚无理想的药物逆转病情。为了提高早期诊断效率,近年来针对该病早期生物标志物的研究成为了热点。除了已确定的β-淀粉样蛋白(Aβ)及微管相关蛋白tau蛋白外,目前也发现了微小RNA(miRNA)可能作为潜在生物标志物。

Alzheimer′s disease(AD)is a degenerative neurodegenerative disease of the central nervous system.The disease is concealed.Patients often experienced several years or even more than ten years of course evolution from the beginning of pathological changes to clinical symptoms.Once entering the stage of dementia,there is no ideal drug to reverse the disease.In order to improve the efficiency of early diagnosis,the research on early biomarkers of the disease has become a hot topic in recent years.In addition to the Aβand tau,microRNAs have been discovered as potential biomarkers of AD.