来曲唑联合小剂量尿促性素促排卵方案对夫精人工授精不孕患者临床妊娠及活产率的影响

Effect of the ovulation induction program of letrozole combined with low-dose menotrophin on clinical pregnancy and live birth rate in infertile patients with artificial insemination by husband

[目的]探讨来曲唑联合小剂量尿促性素促排卵方案对夫精人工授精(AIH)不孕患者临床妊娠及活产率的影响。[方法]将2017年3月至2019年10月于某医院采取来曲唑促排卵方案的34例AIH不孕患者纳入对照组,另将同期采取来曲唑联合小剂量尿促性素促排卵方案治疗的33例AIH不孕患者纳入观察组。比较两组患者人绒毛膜促性腺激素(HCG)日优势卵泡数、子宫内膜厚度;随访至术后30 d,比较两组患者临床妊娠率、流产率,并随访至分娩后,比较两组活产率。[结果]观察组患者HCG日优势卵泡数、子宫内膜厚度高于对照组,差异有统计学意义(P<0.05);观察组患者临床妊娠率、活产率(85.29%、89.66%)高于对照组(60.61%、50.00%),流产率(5.88%)低于对照组(27.27%),差异有统计学意义(P<0.05)。[结论]对AIH不孕患者采取来曲唑联合小剂量尿促性素促排卵方案,可提高患者HCG日优势卵泡数与子宫内膜厚度,提高患者临床妊娠率与活产率,降低流产发生率。

[Objective]To investigate the effect of the ovulation induction program of letrozole combined with low-dose menotrophin on clinical pregnancy and live birth rate in infertile patients with artificial insemination by husband(AIH).[Methods]A retrospective analysis was conducted,34 AIH infertile patients who received the ovulation induction program of letrozole in a hospital from March 2017 to October 2019 were included in the control group,in addition,33 cases of AIH infertile patients who received the ovulation induction program of letrozole combined with low-dose menotrophin at the same period were included in the observation group.The number of dominant follicles per day of human chorionic gonadotropin(HCG)and endometrial thickness of patients in the two groups were compared;followed up to 30 days after surgery,the clinical pregnancy rate and abortion rate were compared of patients in the two groups,and followed to the end of delivery,the live birth rate was compared between the two groups.[Results]The number of dominant follicles in the day of HCG and endometrial thickness of patients in the observation group were significantly higher than the control group,the difference was significant statistically(P<0.05);the clinical pregnancy rate and live birth rate of the observation group(85.29%,89.66%)were higher than those of the control group(60.61%,50.00%),and the abortion rate(5.88%)was lower than that of the control group(27.27%),the difference was significant statistically(P<0.05).[Conclusion]The ovulation induction program of letrozole combined with lowdose menotrophin in patients with AIH can improve the number of dominant follicles per day of HCG and endometrial thickness of patients,improve their clinical pregnancy rate and live birth rate,and reduce the incidence of abortion.