前列腺癌磁共振动态增强定量研究

Quantitative Study of Dynamic Contrastenhanced Magnetic Resonance Imaging in Prostate Cancer

目的研究磁共振动态增强扫描(DCE-MRI)定量分析在前列腺癌临床诊断中的应用价值。方法选取2016年1月至2019年1月于我院收治的80例经病理证实的前列腺疾病患者(其中前列腺癌56例,前列腺增生24例)为研究对象,分析前列腺癌组与前列腺增生组DCE-MRI定量参数容积转运常数(K^(trans))、速率常数(K_(ep))、血管外细胞外间隙容积分数(V_(e))变化情况,检验前列腺癌区K^(trans)与病理Gleason评分的相关性。结果前列腺癌组K^(trans)、K_(ep)、V_(e)值均显著高于前列腺增生组(P<0.05)。前列腺癌患者Gleason≤7分组K^(trans)显著低于Gleason评分8~9分组、10分组(P<0.05),Gleason评分8~9分组K^(trans)值显著低于10分组(P<0.05)。前列腺癌区K^(trans)与病理Gleason评分呈正相关(r=0.690,P=0.000)。结论 DCE-MRI定量分析在前列腺癌诊断中具有重要应用价值,需引起临床重视。

Objective To study the value of quantitative analysis of dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI)in clinical diagnosis of prostate cancer.Methods From January 2016 to January 2019,80 patients with pathologically confirmed prostatic diseases(including 56 cases of prostate cancer,and 24 cases of benign prostatic hyperplasia)were enrolled in our hospital.The changes of DCE-MRI quantitative parameters such as volume transport constant(Ktrans),rate constant(Kep)and extracellular space volume integral(Ve)in prostate cancer group and benign prostatic hyperplasia group were analyzed.The correlation between Ktrans in prostate cancer area and pathological Gleason score.Results The values of Ktrans,Kep,and Ve in the prostate cancer group were significantly higher than those in benign prostatic hyperplasia group(P<0.05).Ktrans in group Gleason<7 group was significantly lower than that in the Gleason score 8-9 and 10 group(P<0.05),and Ktrans in group Gleason score 8-9 was significantly lower than that in group 10(P<0.05).Ktrans in prostate cancer was positively correlated with pathological Gleason score(r=0.690,P=0.000).Conclusion Quantitative analysis of DCE-MRI has great value in diagnosising prostate cancer,and should be paid attention to clinically.