中药保留灌肠联合胃管内灌注并持续胃肠减压对胰腺炎患者的临床疗效

Clinical effect of retention enema with traditional Chinese medicine and continuous gastrointestinal decompression in patients with pancreatitis

目的探讨中药保留灌肠联合胃管内灌注中药并持续胃肠减压治疗胰腺炎的效果。方法选取2017年1月-2019年3月都江堰市中医医院收治的急性胰腺炎患者82例作为研究对象。随机分为中药治疗组及西药治疗组。两组患者均接受持续性胃肠减压,西药治疗组患者在此基础上接受常规西医治疗。比较两组患者腹胀症状消失时间、腹痛症状消失时间、肠鸣音恢复时间及住院时间;比较两组患者治疗前及治疗7 d后血清淀粉酶(AMS)、丙氨酸氨基转移酶(ALT)、血肌酐(Scr)、尿素氮(BUN)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)及白细胞介素-8(IL-8)水平;比较两组患者治疗后的疗效及并发症发生情况。结果中药治疗组患者腹胀消失时间、腹痛消失时间、肠鸣音恢复时间及住院时间均短于西药治疗组患者(P <0.05);治疗7 d后,中药治疗组患者AMS、ALT、Scr及BUN水平均低于西药治疗组患者及治疗前(P <0.05);中药治疗组患者血清TNF-α、IL-6及IL-8水平均低于西药治疗组患者及治疗前(P <0.05);中药治疗组患者总有效率高于西药治疗组患者(P <0.05),且并发症发生率低于西药治疗组患者(P <0.05)。结论中药保留灌肠联合胃管内灌注中药并持续胃肠减压治疗胰腺炎的效果显著,能明显改善患者的症状及实验室指标,减少炎症因子的表达,且药物安全稳定,能够促进患者的康复。

Objective To explore the effect of traditional Chinese medicine retention enema combined with gastric tube infusion and continuous gastrointestinal decompression in the treatment of pancreatitis. Methods Eighty two patients with acute pancreatitis in our hospital were randomly divided into the Chinese medicine treatment group and the Western medicine treatment group. Patients in the Western medicine treatment group were received conventional western medicine treatment, and patients in the Chinese medicine treatment group were received traditional Chinese medicine retention enema combined with gastric tube infusion on the basis of the treatment of control group. The time of disappearance of abdominal distension, abdominal pain, borborygmus recovery, and hospital stay were compared between the two groups. AMS, ALT, Scr, BUN, TNF-α, IL-6, and IL-8 levels were compared between the two groups before and 7 days after treatment. The efficacy and complications of the two groups were compared. Results The time of abdominal distension disappearance, abdominal pain disappearance, borborygmus recovery, and hospital stay in the Chinese medicine treatment group were all less than those in the Western medicine treatment group(P < 0.05). After 7 d of treatment, AMS, ALT, Scr, and BUN levels in the Chinese medicine treatment group were lower than those in the Western medicine treatment group(P < 0.05).TNF-α, IL-6, and IL-8 levels in the Chinese medicine treatment group were lower than those in the Western medicine treatment group(P < 0.05). The total effective rate of the Chinese medicine treatment group was higher than that of the Western medicine treatment group(P < 0.05). The incidence of complications in the Chinese medicine treatment group was lower than that in the Western medicine treatment group(P < 0.05). Conclusion Traditional Chinese medicine retention enema combined with gastric tube infusion and continuous gastrointestinal decompression has a significant effect on the treatment of pancreatitis, which can significantly improve the symptoms and laboratory indicators of patients, reduce the expression of inflammatory factors, and promote the recovery of patients, with safe and stable efficacy.