深圳市体检人群骨质疏松症患病状况及其影响因素研究

Osteoporosis Prevalence and Its Influencing Factors Among Physical Examination Population in Shenzhen

目的:分析深圳市体检人群骨质疏松症(osteoporsis,OP)患病状况及影响因素。方法:选取2019年1-12月于北京大学深圳医院健康管理中心体检者16382例。建立信息采集表,记录性别、年龄、体重指数(BMI)、有无高血压、糖化血红蛋白、总胆固醇、甘油三酯、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、骨密度等检测数据,分析研究对象骨量分布情况及OP影响因素。结果:16382例研究对象中,检出骨质正常11200例(68.4%),骨量减少4026例(24.6%),骨质疏松症1156例(7.1%)。该院体检人群OP患病率为7.1%,其中男性OP患病率为1.5%(154/10514),女性为17.1%(1002/5868)。同年龄段人群,女性OP患病率大于男性。随着年龄增长OP患病率增加。不同骨量者年龄、性别、BMI、有无高血压、糖化血红蛋白及高密度脂蛋白胆固醇比较,差异均有统计学意义(P<0.05)。女性、年龄≥50岁、糖化血红蛋白是OP的独立危险因素(P<0.05),BMI是OP的保护因素(P<0.05)。结论:本研究中体检人群OP患病率为7.0%,同年龄段人群,女性OP患病率大于男性。随着年龄增长OP患病率增加。女性、年龄≥50岁、糖化血红蛋白偏高、低体重指数为OP患病高危人群,应当改善生活方式,适当补钙,预防骨质疏松的发生。

Objective:To analyze the prevalence of osteoporsis(OP)and its influencing factors in physical examination population in Shenzhen.Method:A total of 16382 patients underwent physical examination at the health management center of Peking University Shenzhen Hospital from January to December 2019 were selected.Established information collection table.The data of gender,age,body mass index(BMI),hypertension,glycated hemoglobin A1c,total cholesterol,triglyceride,low density lipoprotein cholesterol,high density lipoprotein cholesterol and bone mineral density were recorded to analyze the bone mass distribution of the subjects and the influencing factors of OP.Result:Among the 16382 subjects,11200 cases(68.4%)had normal bone,4026 cases(24.6%)had reduced bone mass,and 1156 case(7.1%)had osteoporosis.The prevalence of OP in the physical examination group was 7.1%,including 1.5%(154/10514)in males and 17.1%(1002/5868)in females.In the same age group,the prevalence of OP in females was higher than that in males.The prevalence of OP increases with age.There were statistically significant differences in age,gender,BMI,hypertension,HbA1c and HDL-C among different bone mass groups(P<0.05).Female,age≥50 years old,and HbA1c were independent risk factors for OP(P<0.05),while BMI was a protective factor for OP(P<0.05).Conclusion:In this study,the prevalence of OP in the physical examination group is 7.0%,and the prevalence of OP in women is higher than that in men in the same age group.The prevalence of OP increases with age.Female,≥50 years old,high HbA1c and low body mass index are high-risk groups of OP.They should improve their lifestyle and take appropriate calcium supplements to prevent the occurrence of osteoporosis.