抗感染联合纤维支气管镜定位吸痰对重症肺炎患者肺功能及炎症反应的影响

Effect of Anti-Infection Combined with Fiberoptic Bronchoscopy Locates Sputum Aspiration on Lung Function and Inflammation Response in Patients with Severe Pneumonia

目的:探讨抗感染联合纤维支气管镜定位吸痰对重症肺炎患者肺功能及炎症反应的影响。方法:选取本院2018年2月-2019年12月74例ICU重症肺炎患者,按入组先后顺序编号,采用单双号将其分为对照组与研究组,每组37例。两组均行抗感染治疗,对照组采用密闭式吸痰管吸痰;研究组采用纤维支气管镜定位吸痰。比较两组的疗效及治疗前和治疗第7天的APACHEⅡ评分、肺动态顺应性(Cdyn)、浅快呼吸指数(RSB)、炎症反应指标。结果:研究组治疗总有效率高于对照组(P<0.05)。治疗第7天,两组APACHEⅡ评分均低于治疗前(P<0.05),且研究组低于对照组(P<0.05);两组Cdyn、RSB均优于治疗前(P<0.05),且研究组均优于对照组(P<0.05);两组IL-6、TNF-α、IL-10及PCT水平均低于治疗前(P<0.05),且研究组均低于对照组(P<0.05)。结论:抗感染联合纤维支气管镜定位吸痰可有效改善重症肺炎患者肺功能,减轻炎症反应,提升疗效。

Objective:To explore the effect of anti-infection combined with fiberoptic bronchoscopy locates sputum aspiration on lung function and inflammation response in patients with severe pneumonia.Method:A total of 74 patients with severe pneumonia from February 2018 to December 2019 in ICU of our hospital were selected.They were numbered according to the sequence of enrollment,and divided into control group and study group by odd and even numbers,37 cases in each group.The two groups were treated with anti-infection therapy.The control group was treated with closed sputum suction tube suction sputum,the study group was treated with fiberoptic bronchoscope locate sputum aspiration.The efficacy was compared between two groups,and the APACHEⅡscore,compliance dynamic(Cdyn),rapid shallow respiratory(RSB)and inflammatory response indexes were compared between the two groups before treatment and at the 7th day of treatment.Result:The total effective rate of treatment of the study group was higher than that of the control group(P<0.05).On the 7th day of treatment,the APACHEⅡscore in both groups were lower than before treatment(P<0.05),and those of study group were lower than those of the control group(P<0.05);Cdyn and RSB in both groups were better than before treatment(P<0.05),and that of study group was better than that of control group(P<0.05);the levels of IL-6,TNF-α,IL-10 and PCT in both groups were lower than those before treatment(P<0.05),and those of the study group were lower than those of the control group(P<0.05).Conclusion:Anti-infection combined with fiberoptic bronchoscopy locates sputum aspiration can effectively improve the lung function of patients with severe pneumonia,reduce the inflammatory response,and improve the curative efficacy.