全乳房切除术对乳腺癌患者临床治疗效果的研究

Clinical Effect of Total Mastectomy on Patients with Breast Cancer

目的:研究全乳房切除术对乳腺癌患者的临床治疗效果。方法:回顾性分析2018年7月-2019年12月本院收诊的80例乳腺癌患者的临床资料,按照手术方式将患者分为对照组(40例,均接受化疗+保乳治疗)和观察组(40例,均接受全乳切除手术)。对比两组患者的治疗效果和相关指标变化情况。结果:观察组术后1年生存率高于对照组,术后1年复发率低于对照组,差异均有统计学意义(P<0.05)。两组患者术后3个月、1年的血清糖类抗原153(carbohydrate antigen 153,CA153)、癌胚抗原(carcinoembryonic antigen,CEA)水平及miR-424的相对表达量均低于术前(P<0.05);术后1年,两组患者CA153、CEA水平及miR-424的相对表达量均低于术后3个月(P<0.05),术后1年观察组上述指标水平均低于对照组,差异均有统计学意义(P<0.05)。结论:对于乳腺癌患者而言,全乳房切除术无疑是一种效果较好的治疗方式,能够有效地将病灶切除,提高患者生存率,降低复发率,将患者身体中的肿瘤因子、核酸分子等控制在相对较低的水平,因此相较于保守治疗,全乳房切除术无疑更具有应用推广价值。

Objective:To study the clinical effect of total mastectomy on patients with breast cancer.Method:The clinical data of 80 breast cancer patients admitted to our hospital from July 2018 to December 2019 were retrospectively analyzed,and the patients were divided into control group (40 cases,all received chemotherapy + breast-conserving treatment) and observation group (40 cases,all received total mastectomy) according to the surgical methods.The treatment effect and the changes of related indexes were compared between the two groups.Result:The 1-year postoperative survival rate of the observation group was higher than that of the control group,and the 1-year postoperative recurrence rate was lower than that of the control group,the differences were statistically significant (P<0.05).The serum carbohydrate antigen 153 (CA153) and carcinoembryonic antigen (CEA) levels and the relative expression level of miR-424 in two groups were lower than those before surgery (P<0.05);at 1 year postoperatively,the levels of CA153,CEA and the relative expression of miR-424 in the two groups were lower than those in 3 months postoperatively (P<0.05),1 year after operation,the above indexes in the observation group were lower than those in the control group,the differences were statistically significant (P<0.05).Conclusion:Total mastectomy for breast cancer patients is undoubtedly a good treatment effect,can effectively remove lesions,improve the patients survival rate,reduce the recurrence rate,the patients’ tumors in the body factor,nucleic acids and other control in a relatively low level,so compared with conservative treatment,total mastectomy certainly has more application promotion value.