子宫内膜异位症患者应用丹归逐瘀汤治疗对其内分泌激素含量及免疫因子水平的影响

Effect of Danguizhuyu Decoction on the Level of Endocrine Hormone and Immune Factor in Patients with Endometriosis

目的:探讨子宫内膜异位症患者应用丹归逐瘀汤治疗对其内分泌激素含量及免疫因子水平的影响。方法:选取2018年8月-2020年1月本院收治的122例子宫内膜异位症患者。采用随机数字表法将患者分为对照组61例和研究组61例。对照组应用常规药物治疗,研究组应用丹归逐瘀汤治疗。对比两组在应用不同方法治疗后对内分泌激素含量及免疫因子水平的影响,分析其治疗效果。结果:治疗后,两组的LH、FSH、P水平比较,差异均无统计学意义(P>0.05);治疗后,研究组T、PRL水平均低于对照组,E_(2)水平高于对照组,差异均有统计学意义(P<0.05)。治疗后,研究组C3、C4、IL-6、TNF-α、hs-CPR水平均低于对照组,IgG、IgA、IgM水平均高于对照组,差异均有统计学意义(P<0.05)。研究组总有效率高于对照组,差异有统计学意义(P<0.05)。结论:在子宫内膜异位症的治疗中,应用丹归逐瘀汤,能够更好改善患者的内分泌激素含量及免疫因子水平,进而提高治疗效果,值得临床进一步推广应用。

Objective:To investigate the effect of Danguizhuyu Decoction on the level of endocrine hormone and immune factor in patients with endometriosis.Method:A total of 122 endometriosis patients admitted to our hospital from August 2018 to January 2020 were selected.The patients were divided into control group 61 cases and study group 61 cases by random number table method.The control group was treated with conventional drugs,and the study group was treated with Danguizhuyu Decoction.The effects of different treatment methods on the levels of endocrine hormones and immune factors in the two groups were compared,and the therapeutic effects were analyzed.Result:After treatment,there were no significant differences in the levels of LH,FSH and P between the two groups(P>0.05).After treatment,T and PRL levels in the study group were lower than those in the control group,and E_(2) levels were higher than those in the control group,the differences were statistically significant(P<0.05).After treatment,the levels of C3,C4,IL-6,TNF-αand hs-CPR in the study group were lower than those in the control group,and the levels of IgG,IgA and IgM were higher than those in the control group,the differences were statistically significant(P<0.05).The total effective rate of study group was higher than that of control group,the difference was statistically significant(P<0.05).Conclusion:In the treatment of endometriosis,the application of Danguizhuyu Decoction can better improve the endocrine hormone content and immune factor level of patients,and further improve the therapeutic effect,which is worthy of further clinical promotion and application.