血生化指标和纤维化指标在肝硬化患者中的表达价值分析及临床意义研究

Study on the Expression Value and Clinical Significance of Blood Biochemical Indexes and Fibrosis Indexes in Patients with Liver Cirrhosis

目的:探讨血生化指标和纤维化指标在肝硬化患者中的表达价值及临床意义。方法:选取2019年6-12月本院收治的肝硬化患者300例作为研究组,同时选取相同时间段健康体检的人群300例作为对照组,两组均进行血生化指标和纤维化指标检验。比较两组血生化指标(ADA、AFU、LAP、GLDH、TBIL、ALP、AST、TBA)和纤维化指标(PCⅢ、HA、LN、Ⅳ-C),以及Ⅳ-C、LN、HA、AFP、AFU单独检测和五项联合检测诊断肝硬化的阳性率。结果:研究组PCⅢ、HA、LN、Ⅳ-C、ADA、AFU、LAP、GLDH、TBIL、ALP、AST、TBA均高于对照组,PAB、CHE均低于对照组,差异均有统计学意义(P<0.05)。血清Ⅳ-C、LN、HA、AFP、AFU单独检测的阳性率分别为58.3%、56.7%、52.0%、62.3%、71.0%;五种指标联合检测的阳性检出率为89.7%;五项指标联合检测的阳性率高于各指标单独检测(P<0.05)。结论:在肝硬化患者中,血生化指标以及纤维化指标检验具有一定的诊断价值,临床上应当进一步推广应用。

Objective:To explore the expression value and clinical significance of blood biochemical indexes and fibrosis indexes in patients with cirrhosis.Method:A total of 300 liver cirrhosis patients admitted to our hospital from June to December 2019 were selected as the study group,and 300 healthy people in the same period of time were selected as the control group,blood biochemical indexes and fibrosis indexes were tested in both groups.Blood biochemical indexes (ADA,AFU,LAP,GLDH,TBIL,ALP,AST,TBA) and fibrosis indexes (PCⅢ,HA,LN,Ⅳ-C) were compared between the two groups,and the positive rate of the diagnosis of cirrhosis were compared between the two groups.Result:PCⅢ,HA,LN,Ⅳ-C,ADA,AFU,LAP,GLDH,TBIL,ALP,AST and TBA in the study group were all higher than those in the control group,while PAB and CHE were lower than those in the control group,the differences were statistically significant (P<0.05).The positive rates of serum Ⅳ-C,LN,HA,AFP and AFU were 58.3%,56.7%,52.0%,62.3% and 71.0%,respectively;the positive detection rate was 89.7%,the positive rate of the combination of five indexes was higher than that of each index alone (P<0.05).Conclusion:Blood biochemical indexes and fibrosis indexes have certain diagnostic value in patients with cirrhosis,and should be further promoted and applied in clinical practice.