牙髓血管再生及再血管化的研究进展

Research progress of pulp angiogenesis and revascularization

不可逆性牙髓炎是口腔科常见疾病,临床针对该类患者主要采用根管治疗术,包括根管预备、根管消毒、根管充填3个阶段,其中根管充填是最主要的阶段。其虽可起到一定的治疗效果,但去除牙髓后,牙体组织会变脆、变薄,长时间后会出现患牙折断现象,患者甚至面临拔牙风险。因此,寻求一种既能有效去除牙髓感染,又能保留或重建牙髓功能的方法具有重要意义。近年来,生物组织工程牙髓血管再生、牙髓再血管化在牙髓再生中具有广泛的应用前景,为牙髓再生提供了更多的可能性。本文就以上两种方法作一概述,以期为临床牙髓再生方法的选择提供些许参考。

Irreversible pulpitis is a common disease in stomatology.Root canal therapy is mainly used for this kind of patients in clinic,including root canal preparation,root canal disinfection and root canal filling three stages,in which root canal filling is the most important stage.Although it can play a certain therapeutic effect,after the removal of dental pulp,the tooth tissue will become brittle and thin.After a long time,the teeth will break,and the patients even face the risk of tooth extraction.Therefore,it is of great significance to seek a method that can not only effectively remove pulp infection,but also preserve or reconstruct pulp function.In recent years,biological tissue engineering pulp revascularization and pulp revascularization have been widely used in pulp regeneration,which provides more possibilities for pulp regeneration.In this paper,the above two methods were summarized,in order to provide some reference for the selection of clinical pulp regeneration methods.