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Hypervalent iodine-mediated gem-difluorination of vinyl halides enabled by exclusive 1,2-halo migration 被引量:1

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摘要 β-Difluorinated alkyl halides are of significant value in the modular synthesis of gem-difluorinated molecules.An exclusive 1,2-halo migratory gem-difluorination of vinyl halides with in situ-generated PhIF_(2)·HF is described.This protocol provides a general and practical approach towards a wide variety ofβ-difluorinated alkyl bromides.Bothα-andβ-bromoalkyl alkenes are suitable substrates,leading to two distinct types of products.The extension of this protocol to vinyl chloride and iodide are also feasible.The synthetic versatility of this method has been highlighted by the late-stage modification of complex small molecules and further transformations of theβ-difluorinated alkyl halides to valuable CF_(2)-containing compounds.
出处 《Science China Chemistry》 SCIE EI CSCD 2021年第6期999-1003,共5页 中国科学(化学英文版)
基金 This work was supported by the National Natural Science Foundation of China(21961047,21901266,21971261,22022114).
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