多巴胺在形觉剥夺性近视中作用的研究进展

Research Progress in the Role of Dopamine in Form Deprivation Myopia

近视作为一种全球发病率最高的屈光不正,其趋势日益增加,已成为眼科研究领域的热点。形觉剥夺性近视是实验性近视中较为成熟的造模方法。众多研究报道多巴胺作为一种调控视网膜及眼球生长微环境的神经递质,通过与多巴胺受体、途径间的相互作用,在形觉剥夺性近视的形成和抑制过程中具有重要意义。现就多巴胺对形觉剥夺性近视的影响及其生化机制进行探讨,以期为近视的实验研究提供参考。

Myopia is a refractive error with the highest incidence in the world,and its trend is increasing,which has become a hot spot in the field of ophthalmology research.Form deprivation myopia is a mature method in experimental myopia.Many studies have reported that dopamine,as a neurotransmitter regulating the growth microenvironment of retina and eyeball,plays an important role in the formation and inhibition of form deprivation myopia through the interaction with dopamine receptors and pathways.In this paper,the effect of dopamine on form deprivation myopia and its biochemical mechanism were discussed,in order to provide a reference for the experimental study of myopia.