免疫球蛋白E型自身抗体在自身免疫相关皮肤病中的研究进展

Role of immunoglobulin E autoantibodies in autoimmune skin diseases

大量研究显示,免疫球蛋白E(IgE)不但参与变态反应的发生发展,还可通过多种机制诱发和加重自身免疫反应。IgE型自身抗体已证实可在多种自身免疫相关皮肤病中出现,可能通过与自身抗原结合影响树突细胞、肥大细胞、嗜碱性粒细胞等多种免疫机制参与相关疾病的发生发展。本文综述IgE在系统性红斑狼疮、大疱性类天疱疮以及慢性特发性荨麻疹等自身免疫相关皮肤病的诱发和加重中所起的作用和可能机制,为临床诊治提供理论基础。

A large number of studies have shown that immunoglobulin E(IgE)not only participates in the occurrence and development of allergic reactions,but also induces and aggravates autoimmune reactions through various mechanisms.IgE autoantibodies have been confirmed to be present in a variety of autoimmune skin diseases,and may be involved in the occurrence and development of related diseases by affecting multiple immune cells such as dendritic cells,mast cells,and basophils via binding to autoantigens.This review summarizes the role and possible mechanism of action of IgE in the induction and exacerbation of autoimmune skin diseases such as systemic lupus erythematosus,bullous pemphigoid and chronic idiopathic urticaria,and provides a theoretical basis for clinical diagnosis and treatment.