浙江地区120245例检测新型冠状病毒血清抗体阳性率分析

Seroprevalence of antibodies against SARS-CoV-2 in 120245 cases from Zhejiang province

目的了解浙江地区新型冠状病毒血清抗体阳性率概况,以期找到后续抗体监测重点。方法回顾性分析浙江地区120245例新型冠状病毒血清抗体结果,依照样本来源、年龄、性别分组,探究浙江地区人群IgG血清抗体单阳性率、IgM血清抗体单阳性率和IgG与IgM血清抗体双阳性率。结果在浙江地区120245例研究对象中,发热门诊、新住院及陪护人员占比最多,年龄以30~50岁为主,IgG抗体单阳性率为0.11%,IgM抗体单阳性率为0.15%,IgG、IgM抗体双阳性率为0.13%。依照样本来源分组,发热门诊新住院及陪护人员IgG、IgM血清抗体单阳性率最高,隔离点人员IgG和IgM血清抗体双阳性率最高(0.16%);依照年龄性别分组,男性组IgG单阳性率与IgG、IgM双阳率高于女性组,且差异有统计学意义;与>50岁组相比,其他各组IgG单阳性率、IgM单阳性率、IgG和IgM双阳性率均更低,且差异有统计学意义。在检出率较高的温州地区,血清抗体IgG单阳性率(0.14%),IgM单阳性率(0.15%),IgG、IgM双阳性率(0.25%)均高于全省水平,且隔离点人员的IgM单阳性率及IgG、IgM双阳性率与医疗机构工作人员相比差异有统计学意义,男性血清抗体IgG单阳性率,IgM单阳性率,IgG、IgM双阳性率均高于女性,年龄分组可看出30岁~50岁人群阳性率较全省更高。结论虽然浙江地区新型冠状病毒血清抗体阳性率较低,但隔离点人员和发热门诊新住院及陪护人员阳性率较高,尤其是年龄在50岁以上的人群。为避免疫情再次暴发,疫情防控工作仍需高度重视。

Objective To understand the seroprevalence against antibodies to SARS-CoV-2 in Zhejiang, in order to find the key point of subsequent antibody monitoring. Methods The results of novel coronavirus serum antibodies in 120 245 cases were retrospectively analyzed. The single-positive rate of IgG serum antibody, single-positive rate of IgM serum antibody and double positive rate of IgG and IgM serum antibody in Zhejiang area were investigated according to the sample source, age, and gender.Results Among the 120 245 study subjects in Zhejiang area, fever clinics, new hospitalizations and accompanying persons accounted for the most. The age was mainly 30~50 years old. The single positive rate of IgG antibody was 0.11%, the single positive rate of IgM antibody was 0.15%, and the double positive rate of IgG and IgM antibody was 0.13%. Grouped according to the sample source, the single positive rate of IgG and IgM serum antibodies for newly hospitalized and accompanying persons in fever clinics was the highest,and the double positive rate of IgG and IgM serum antibodies for people in isolation points was the highest(0.16%). Grouped by age and gender, the single positive rate of IgG in the female group compared with IgG and IgM, the double positive rate was higher than that of the male group, and the difference was statistically significant. Compared with the group more than 50 years old, the other groups had lower IgG single-positive rates, IgM single-positive rates, IgG and IgM double-positive rates, and the difference was statistically significant. In Wenzhou area with high detection rate, the single positive rate of serum antibody IgG(0.14%),the single positive rate of IgM(0.15%), and the double positive rate of IgG and IgM(0.25%) were all higher than the provincial level. In addition, the IgM single-positive rate and the IgG, IgM double-positive rate of the personnel at the isolation point were statistically different from those of the medical institution staff. The male serum antibody IgG single-positive rate, IgM single-positive rate, IgG, IgM double-positive rate were all higher than those of women. The age group showed that the positive rate of people aged 30-50 is higher than that of the whole province. Conclusion Although the positive rate of new coronavirus seroantibodies was low in Zhejiang, the positive rate of quarantine personnel and new hospitalized and accompanying persons in fever clinics is relatively high, especially in people over 50 years old. In order to avoid another outbreak, epidemic prevention and control work still requires great attention.