白蛋白尿与缺血性卒中关系的研究进展

Progress on the Relationship between Albuminuria and Ischemic Stroke

缺血性卒中是世界范围内病残率最高的疾病之一。颈部或颅底大动脉粥样硬化是缺血性卒中的首要病因。既往研究提示,微量白蛋白尿不仅是全身血管内皮功能紊乱的重要标志,还可能是动脉粥样硬化发生的早期标志。近年来研究发现,白蛋白尿与缺血性卒中的发生、发展及预后均存在密切联系。本文旨在对白蛋白尿与缺血性卒中关系的研究进展进行综述。

Ischemic stroke is one of the most leading diseases with high morbidity and disability worldwide.Extra-and-intracranial large artery atherosclerosis is the primary cause of ischemic stroke.Previous studies have suggested that microalbuminuria is not only an important marker of generalized endothelial dysfunction,but also an early marker of atherosclerosis.More recently,many studies have found that albuminuria is closely linked to the pathogenesis,progression and prognosis of ischemic stroke.This article aimed to review the research advances in the relationship between albuminuria and ischemic stroke.