新疆生产建设兵团某师30岁以上常住居民高尿酸血症随机抽样调查

A random sampling survey of hyperuricemia among permanent residents over 30 years old in a division of Xinjiang Production and Construction Corps

目的探讨新疆生产建设兵团(以下简称兵团)某师常住居民高尿酸血症的患病率及影响因素,为预防高尿酸血症提供依据。方法选取2014年11月至2015年3月兵团某师年满30岁的常住居民(居住时间>6个月),采用多阶段分层随机抽样调查,最终纳入4650例调查对象。比较男、女的尿酸(UA)水平差异及高尿酸血症患病率;分析不同性别相同年龄段、相同性别相邻年龄段间UA水平差异;比较男、女高尿酸血症患者和UA水平正常者的一般资料与实验室指标;采用多因素Logistic回归分析男、女发生高尿酸血症的影响因素。结果男性UA水平、高尿酸血症患病率明显高于女性,差异有统计学意义(P<0.05)。相同年龄段中,男性UA水平均高于女性,差异有统计学意义(P<0.05)。男性高尿酸血症患者的体质量指数(BMI)、UA、肌酐(Cr)、总胆固醇(TC)、三酰甘油(TG)、丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)和空腹血糖(FBG)水平均高于UA水平正常者,高密度脂蛋白(HDL)水平低于UA水平正常者,差异有统计学意义(P<0.05)。女性高尿酸血症患者年龄、BMI、UA、Cr、TC、TG、ALT、AST和FBG水平均高于UA水平正常者,HDL水平低于UA水平正常者,差异有统计学意义(P<0.05)。高血压和高脂血症均是男、女发生高尿酸血症的独立危险因素(P<0.05)。结论男性是高尿酸血症的高发人群,高血压和高脂血症是高尿酸血症发生的独立危险因素。

Objective To explore the prevalence and influencing factors of hyperuricemia in the permanent residents of a division of Xinjiang Production and Construction Corps(hereinafter referred to as the Corps),and provide evidence for the prevention of hyperuricemia.Methods Selected permanent residents(residence time>6 months)of a division of the Corps from November 2014 to March 2015 who had reached the age of 30,and adopted a multi-stage stratified random sampling survey,and finally included 4650 survey subjects.Compared the differences in uric acid(UA)levels and the prevalence of hyperuricemia between male and female.Analyzed the differences in UA levels between the same age group of different gender,adjacent age group of same gender.Compared the general data and laboratory indicators between male and female patients with hyperuricemia and people with normal UA levels.Multivariate Logistic regression was used to analyze the influencing factors of hyperuricemia in male and female.Results The level of UA and the prevalence of hyperuricemia in male were significantly higher than those in female,and the difference was statistically significant(P<0.05).The UA level in male was higher than that in female of the same age group,and the difference was statistically significant(P<0.05).The body mass index(BMI),UA,creatinine(Cr),total cholesterol(TC),triglyceride(TG),alanine aminotransferase(ALT),aspartate aminotransferase(AST)and fasting blood glucose(FBG)levels in male patients with hyperuricemia were higher than male with normal UA level,and the high density lipoprotein(HDL)level was lower than male with normal UA level,the differences were statistically significant(P<0.05).The age,BMI,UA,Cr,TC,TG,ALT,AST and FBG levels in female patients with hyperuricemia were higher than female with normal UA level,and the HDL level was lower than female with normal UA level,the differences were statistically significant(P<0.05).Hypertension and hyperlipidemia were independent risk factors for the occurrence of hyperuricemia in male and female(P<0.05).Conclusion Male is a high risk population of hyperuricemia,hypertension and hyperlipidemia are independent risk factors of hyperuricemia.