何氏穴位敷贴验方治疗过敏性鼻炎的疗效及对患者免疫功能的影响

Treatment effect of He′s acupoint application on allergic rhinitis and its influence on immune function of patients

目的探讨何氏穴位敷贴验方治疗过敏性鼻炎的疗效及对患者免疫功能的影响。方法选择2019年1月1日至2月28日于该院五官科门诊就诊的过敏性鼻炎患者100例为过敏性鼻炎组,采用随机数字表法又将过敏性鼻炎组患者分为观察组和对照组,各50例;另选取同期健康体检者100例为健康组。检测研究对象嗜酸性粒细胞百分比(EOS)、白细胞介素(IL)-2、IL-4、IL-10、IL-6、肿瘤坏死因子α(TNF-α)、干扰素γ(IFN-γ)、免疫球蛋白E(IgE)、特异性免疫球蛋白E(sIgE)和嗜酸性粒细胞阳离子蛋白(ECP)。比较治疗前过敏性鼻炎组与健康组的免疫学指标;比较对照组与观察组治疗前后的免疫学指标及临床疗效。结果治疗前过敏性鼻炎组IL-6、EOS、IgE、sIgE、ECP水平高于健康组,TNF-α水平低于健康组,差异有统计学意义(P<0.05)。观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。观察组治疗后IL-6、EOS、IgE、sIgE、ECP水平低于治疗前,TNF-α水平高于治疗前,差异有统计学意义(P<0.05)。对照组治疗后IgE、sIgE水平低于治疗前,差异有统计学意义(P<0.05)。观察组治疗后IL-6、EOS、IgE、sIgE、ECP水平低于对照组治疗后,TNF-α水平高于对照组治疗后,差异有统计学意义(P<0.05)。结论采用何氏穴位敷贴验方治疗过敏性鼻炎的疗效好,还可改善患者的免疫功能,值得临床推广应用。

Objective To explore the treatment effect of He′s acupoint application on allergic rhinitis and its influence on the immune function of patients.Methods A total of 100 patients with allergic rhinitis who treated in the department of ophthalmology and otorhinolaryngology of the hospital from January 1st to February 28th,2019 were selected as the allergic rhinitis group,and the patients in the allergic rhinitis group were divided into the observation group and the control group by the random number table method,with 50 cases in each group.In addition,100 healthy people who had physical examination during the same period were selected as the healthy group.Detected the percentage of eosinophils(EOS),interleukin(IL)-2,IL-4,IL-10,IL-6,tumor necrosis factorα(TNF-α),interferonγ(IFN-γ),immunoglobulin E(IgE),specific immunoglobulin E(sIgE)and eosinophil cationic protein(ECP)of study objects.Compared the immunological indicators between the allergic rhinitis group before treatment and the healthy group.Compared the clinical efficacy and immunological indicators before and after treatment between the control group and the observation group.Results Before treatment,the levels of IL-6,EOS,IgE,sIgE and ECP in the allergic rhinitis group were higher than those in the healthy group,and the level of TNF-αwas lower than that in the healthy group,the differences were statistically significant(P<0.05).The total treatment effective rate of the observation group was higher than that of the control group,and the differences were statistically significant(P<0.05).The levels of IL-6,EOS,IgE,sIgE and ECP in the observation group after treatment were lower than those before treatment,and the level of TNF-αwas higher than that before treatment,the differences were statistically significant(P<0.05).The levels of IgE and sIgE in the control group after treatment were lower than those before treatment,and the differences were statistically significant(P<0.05).After treatment,the levels of IL-6,EOS,IgE,sIgE and ECP in the observation group were lower than those in the control group,and the level of TNF-αwas higher than that in the control group,the differences were statistically significant(P<0.05).Conclusion The use of He′s acupoint application to treat allergic rhinitis has a good treatment effect and can also improve the immune function of patients.It is worthy of clinical application.