期刊文献+

经络病机与证候新药评价 被引量:5

Channel pathogenesis and syndrome new drug evaluation
原文传递
导出
摘要 经络病机以经络学说为依据,横向参合脏腑、气血津液等理论,反映疾病发生发展及变化转归的机制,能更好体现证候的时空转化轨迹。证候新药是以证候为基点纵向贯穿多种疾病的一类新药,其常用评价方式存在评价指标量化的问题,不能反映证候动态演进等,制约其进一步发展。笔者在完善证候新药评价模式的探索中发现,经络病机契合证候新药评价发展的内在要求,但前人未予以重视,淡化其临床地位。发展基于经络病机的证候新药评价,并结合现代临床科研方法学,有利于构建综合多维的评价体系,有利于形成互为印证的评价模式,有利于证候新药研发与技术审评体系的建设。 The channel pathogenesis is based on the meridian theory,lateral involvement in syndrome differentiation of zang-fu viscera,qi-blood fluid theory,and so on.The theory not only reflect the mechanism of disease occurrence and development,but also can reflect the temporal and spatial transformation trajectory of syndromes.Syndrome new drugs are a new class of drugs that run through a variety of diseases in a longitudinal direction.The common evaluation methods have many problems in the evaluation of quantitative indicators,that cannot reflect the dynamic evolution of syndromes,which restricts their further development.In the exploration of perfecting the new drug evaluation model,it is found that the channel pathogenesis fits the inherent requirements of the development of the syndrome new drug evaluation,but the predecessors did not pay attention to it and disregarded its clinical status.The development of the syndrome new drug evaluation based on channel pathogenesis,that combine with modern clinical research methodology,which is conducive to the construction of a comprehensive multidimensional evaluation system,the formation of mutually validated evaluation model,and the development of syndrome new drugs and the construction of technical review system.
作者 汪海 祝捷 由凤鸣 严然 郑川 夏孟蛟 WANG Hai;ZHU Jie;YOU Feng-ming;YAN Ran;ZHENG Chuan;XIA Meng-jiao(Chengdu University of TCM,Chengdu 610075,China;Hospital of Chengdu University of Traditional Chinese Medicine,Chengdu 610075,China;Cancer Institute of Chengdu University of TCM,Chengdu 610075,China;University of Leeds,Leeds LS29JT,England)
出处 《中华中医药杂志》 CAS CSCD 北大核心 2021年第5期2453-2455,共3页 China Journal of Traditional Chinese Medicine and Pharmacy
基金 国家自然科学基金项目(No.81774284,No.81803994)。
关键词 经络病机 证候新药 证候新药评价 证候 证候量 Channel pathogenesis Syndrome new drug Syndrome new drug evaluation Syndrome Syndrome quantification
  • 相关文献

参考文献7

二级参考文献75

共引文献189

同被引文献89

引证文献5

二级引证文献9

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部